Journal
CEREBRAL CORTEX
Volume 31, Issue 4, Pages 1953-1969Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhaa332
Keywords
aging; atrophy; cortex; sleep
Categories
Funding
- EU [732592]
- European Research Council [283634, 725025, 313440, 677804]
- Norwegian Research Council
- National Association for Public Health's dementia research program, Norway
- Medical Student Research Program at the University of Oslo
- Knut and Alice Wallenberg (KAW) foundation
- Spanish Ministry of Economy and Competitiveness (MINECO) [PSI2015-64227-R]
- Walnuts and Healthy Aging study - California Walnut Commission, Sacramento, California [NCT01634841]
- German Federal Ministry of Education and Research [16SV5537/16SV5837/16SV5538/16SV5536K/01UW0808/01UW0706/01GL1716A/01GL1716B]
- Wellcome Trust [203139/Z/16/Z]
- UK Medical Research Council [G1001354]
- HDH Wills 1965 Charitable Trust [1117747]
- UK Alzheimer's Society Research Fellowship [441]
- NIHR Oxford Health Biomedical Research Centre
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904]
- DOD ADNI (Department of Defense) [W81XWH-12-2-0012]
- National Institute of Biomedical Imaging and Bioengineering
- AbbVie
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Araclon Biotech
- BioClinica, Inc.
- Biogen
- Bristol-Myers Squibb Company
- CereSpir, Inc.
- Cogstate
- Eisai Inc.
- Elan Pharmaceuticals, Inc.
- Eli Lilly and Company
- EuroImmun
- F. Hoffmann-La Roche Ltd
- Genentech, Inc.
- Fujirebio
- GE Healthcare
- IXICO Ltd
- Janssen Alzheimer Immunotherapy Research & Development, LLC
- Johnson& Johnson Pharmaceutical Research & Development LLC
- Lumosity
- Lundbeck
- Merck Co., Inc.
- Meso Scale Diagnostics, LLC.
- NeuroRx Research
- Neurotrack Technologies
- Novartis Pharmaceuticals Corporation
- Pfizer Inc.
- Piramal Imaging
- Servier
- Takeda Pharmaceutical Company
- Transition Therapeutics
- Canadian Institutes of Health Research
- ADNI (National Institutes of Health) [U01 AG024904]
- National Institute on Aging
- European Research Council (ERC) [677804] Funding Source: European Research Council (ERC)
- MRC [MR/K013351/1, G1001354] Funding Source: UKRI
Ask authors/readers for more resources
The study found that self-reported sleep quality and sleep disturbances were associated with thinning of the right lateral temporal cortex, with this association becoming more pronounced with age. Sleep disturbances were particularly evident after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons.
We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18-92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and relations to changes in memory performance. PSQI # 1 Subjective sleep quality and PSQI #5 Sleep disturbances were related to thinning of the right lateral temporal cortex, with lower quality and more disturbances being associated with faster thinning. The association with PSQI #5 Sleep disturbances emerged after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons. None of the sleep scales were related to a longitudinal change in episodic memory function, suggesting that sleep-related cortical changes were independent of cognitive decline. The relationship to cortical brain change suggests that self-reported sleep parameters are relevant in lifespan studies, but small effect sizes indicate that self-reported sleep is not a good biomarker of general cortical degeneration in healthy older adults.
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