Journal
CEREBRAL CORTEX
Volume 31, Issue 4, Pages 2251-2267Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhaa358
Keywords
hippocampus; intracerebral microinfusion; macaque; parahippocampal cortex; spatial memory
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Funding
- National Institute of Mental Health [R01MH099505, R01MH120638]
- National Center for Advancing Translational Sciences at the National Institutes of Health [TL1TR001431]
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The study discovered the critical role of parahippocampal cortex (PHC) and hippocampus in nonnavigational spatial memory. Through pharmacological inactivation of PHC and functional disconnection experiments, it was found that both play important roles in maintaining long-term spatial memory.
The Hamilton Search Task (HST) is a test of nonnavigational spatial memory that is dependent on the hippocampus. The parahippocampal cortex (PHC) is a major route for spatial information to reach the hippocampus, but the extent to which the PHC and hippocampus function independently of one another in the context of nonnavigational spatial memory is unclear. Here, we tested the hypotheses that (1) bilateral pharmacological inactivation of the PHC would impair HST performance, and (2) that functional disconnection of the PHC and hippocampus by contralateral (crossed) inactivation would likewise impair performance. Transient inactivation of the PHC impaired HST performance most robustly with 30 s intertrial delays, but not when color cues were introduced. Functional disconnection of the PHC and hippocampus, but not separate unilateral inactivation of either region, also selectively impaired long-term spatial memory. These findings indicate a critical role for the PHC and its interactions with the hippocampus in nonnavigational spatial memory.
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