Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 18, Issue 2, Pages 259-268Publisher
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/s41423-020-00585-5
Keywords
Aryl hydrocarbon receptor; Autoimmune diseases; Infectious diseases; cancer
Categories
Funding
- NIH [NS102807, ES02530, ES029136, AI126880]
- NMSS [RG-1902-33606]
- International Progressive MS Alliance [PA-1604-08459]
- Santander Universidades
- FundacAo Faculdade de Medicina (FFM), SAo Paulo, SP, Brazil
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The aryl hydrocarbon receptor (AHR) was originally identified as the receptor for dioxin and is now known to be a receptor for multiple physiological ligands, playing crucial roles in health and disease. AHR has been found to play a role in the gut-brain axis and could hold potential as a therapeutic target for immune-mediated diseases.
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the role of AHR in the gut-brain axis and its potential value as a therapeutic target for immune-mediated diseases.
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