Journal
CELL STEM CELL
Volume 28, Issue 1, Pages 5-7Publisher
CELL PRESS
DOI: 10.1016/j.stem.2020.12.006
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The study demonstrates that epigenetic reprogramming of RGCs by overexpressing Oct4, Sox2, and Klf4 can lead to axon regeneration and restoration of vision in a glaucoma model and aged mice.
The regeneration potential of axons projecting from retinal ganglion cells (RGCs) is lost shortly after birth. In Nature, Lu et al. (2020) demonstrate that epigenetic reprogramming of RGCs by overexpression of Oct4, Sox2, and Klf4 leads to axon regeneration and restoration of vision in a glaucoma model and aged mice.
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