Journal
CELL METABOLISM
Volume 33, Issue 1, Pages 21-32Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2020.11.010
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Funding
- Advanced/Transplant Hepatology Award
- Alan Hofmann Clinical, Translational, and Outcomes Research Award from the American Association for the Study of Liver Diseases (AASLD) Foundation
- NIEHS [5P42ES010337]
- NCATS [5UL1TR001442]
- NIDDK [R01DK106419, P30DK120515, P30 DK120515]
- DOD PRCRP [CA170674P2]
- CDMRP [CA170674P2, 1100671] Funding Source: Federal RePORTER
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Nonalcoholic fatty liver disease (NALFD) is a leading cause of chronic liver disease worldwide, associated with rapidly rising levels of obesity and metabolic syndrome, and is a major risk factor for cirrhosis, hepatocellular carcinoma, and liver-related mortality. The gut microbiome is intricately linked to the pathogenesis of NAFLD, and can be leveraged for personalized disease management strategies.
Nonalcoholic fatty liver disease (NALFD) is now a leading cause of chronic liver disease worldwide, in part, as a consequence of rapidly rising levels of obesity and metabolic syndrome and is a major risk factor for cirrhosis, hepatocellular carcinoma, and liver-related mortality. From NAFLD stems a myriad of clinical challenges related to both diagnosis and management. A growing body of evidence suggests an intricate linkage between the gut microbiome and the pathogenesis of NAFLD. We highlight how our current knowledge of the gut-liver axis in NAFLD may be leveraged to develop gut microbiome-based personalized approaches for disease management, including its use as a non-invasive biomarker for diagnosis and staging, as a target for therapeutic modulation, and as a marker of drug response. We will also discuss current limitations of these microbiome-based approaches. Ultimately, a better understanding of microbiota-host interactions in NAFLD will inform the development of novel preventative strategies and precise therapeutic targets.
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