Interleukin-17 receptor D (Sef) is a multi-functional regulator of cell signaling

Interleukin-17 receptor D (IL17RD or IL-17RD) also known as Sef (similar expression to fibroblast growth factor), is a single pass transmembrane protein that is reported to regulate several signaling pathways. IL17RD was initially described as a feedback inhibitor of fibroblast growth factor (FGF) signaling during zebrafish and frog development. It was subsequently determined to regulate other receptor tyrosine kinase signaling cascades as well as several proinflammatory signaling pathways including Interleukin-17A (IL17A), Toll-like receptors (TLR) and Interleukin-1 alpha (IL1 alpha) in several vertebrate species including humans. This review will provide an overview of IL17RD regulation of signaling pathways and functions with emphasis on regulation of development and pathobiological conditions. We will also discuss gaps in our knowledge about IL17RD function to provide insight into opportunities for future investigation.

Automated summary

IL17RD, also known as Sef, is a transmembrane protein that regulates multiple signaling pathways, particularly in developmental and pathobiological contexts, including the modulation of proinflammatory pathways such as IL17A. Despite its known functions, there are still gaps in our understanding of IL17RD, presenting opportunities for further research.