A Crisp(r) New Perspective on SARS-CoV-2 Biology

Complementary genome-wide CRISPR-Cas9 screens performed by multiple groups reveal new insights into SARS-CoV-2 biology including aspects of viral entry, translation, replication, egress, and the genes regulating these processes. Comparisons with other coronaviruses enhances our understanding of the cellular life cycle of this medically important family of emerging viruses.

Automated summary

Complementary genome-wide CRISPR-Cas9 screens conducted by multiple groups have provided new insights into SARS-CoV-2 biology, particularly in viral entry, translation, replication, egress, and the genes involved in regulating these processes. Comparisons with other coronaviruses have furthered our understanding of the cellular life cycle of this important family of emerging viruses.