Journal
CELL
Volume 183, Issue 7, Pages 1946-+Publisher
CELL PRESS
DOI: 10.1016/j.cell.2020.11.019
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Categories
Funding
- Swedish Research Council
- Karolinska Institutet
- Swedish Society for Medical Research
- Jeansson Stiftelse
- Ake Wibergs Stiftelse
- Swedish Society of Medicine
- Cancerfonden
- Barncancerfonden
- Magnus Bergvalls Stiftelse
- Lars Hiertas Stiftelse
- Swedish Physician against AIDS Foundation
- Jonas Soderquist Stiftelse
- Clas Groschinskys Minnesfond
- National Institutes of Health [AI076066, AI118694, AI106481, UC4 DK112217, P01AI131338, U19AI149680, AI105343, AI117950, AI082630, AI112521, AI115712, AI108545, CA210944]
- Stand Up 2 Cancer
- Penn Center for AIDS Research [AI045008]
- BEAT-HIV Delaney Collaboratory [UM1AI126620]
- Wellcome Trust Senior Investigator Award [100326/Z/12/Z]
- Parker Institute for Cancer Immunotherapy
- Wellcome Trust [100326/Z/12/Z] Funding Source: Wellcome Trust
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Lymphocyte migration is essential for adaptive immune surveillance. However, our current understanding of this process is rudimentary, because most human studies have been restricted to immunological analyses of blood and various tissues. To address this knowledge gap, we used an integrated approach to characterize tissue-emigrant lineages in thoracic duct lymph (TDL). The most prevalent immune cells in human and nonhuman primate efferent lymph were T cells. Cytolytic CD8(+) T cell subsets with effector-like epigenetic and transcriptional signatures were clonotypically skewed and selectively confined to the intravascular circulation, whereas non-cytolytic CD8(+) T cell subsets with stem-like epigenetic and transcriptional signatures predominated in tissues and TDL. Moreover, these anatomically distinct gene expression profiles were recapitulated within individual clonotypes, suggesting parallel differentiation programs independent of the expressed antigen receptor. Our collective dataset provides an atlas of the migratory immune system and defines the nature of tissue-emigrant CD8(+) T cells that recirculate via TDL.
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