Journal
CELL
Volume 184, Issue 1, Pages 33-63Publisher
CELL PRESS
DOI: 10.1016/j.cell.2020.11.034
Keywords
-
Categories
Funding
- European Research Council (ERC Advanced Grant, DeAge)
- FEDER/Ministerio de Ciencia, Innovacion y Universidades [SAF2017-87655-R]
- Instituto de Salud Carlos III
- la Caixa'' Foundation [HR17-00221]
- Fundacion Bancaria Caja de Ahorros de Asturias
- Ligue Contre le Cancer (equipe labellisee)
- Agence National de la Recherche (ANR)-Projets blancs
- Association pour la Recherche sur le Cancer (ARC)
- Association Ruban Rose
- Canceropole Ile-de-France
- Chancelerie des universites de Paris (Legs Poix)
- Fondation pour la Recherche Medicale (FRM)
- European Research Area Network on Cardiovascular Diseases (ERA-CVD, MINOTAUR)
- Gustave Roussy Odyssea
- European Union Horizon 2020 Project Oncobiome
- Fondation Carrefour
- Institut National Du Cancer (INCa)
- Inserm (HTE)
- Leducq Foundation
- LabEx ImmunoOncology
- RHU Torino Lumiere
- Seerave Foundation
- SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
Ask authors/readers for more resources
Health is more than just the absence of disease; it involves a combination of organizational and dynamic features that maintain physiology. Biological causes of health include spatial compartmentalization, maintenance of homeostasis, and adequate responses to stress. Disruption of these features can lead to pathogenic processes.
Health is usually defined as the absence of pathology. Here, we endeavor to define health as a compendium of organizational and dynamic features that maintain physiology. The biological causes or hallmarks of health include features of spatial compartmentalization (integrity of barriers and containment of local perturbations), maintenance of homeostasis over time (recycling and turnover, integration of circuitries, and rhythmic oscillations), and an array of adequate responses to stress (homeostatic resilience, hormetic regulation, and repair and regeneration), Disruption of any of these interlocked features is broadly pathogenic, causing an acute or progressive derailment of the system coupled to the loss of numerous stigmata of health.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available