4.8 Review

Adaptive immunity to SARS-CoV-2 and COVID-19

Related references

Note: Only part of the references are listed.
Article Immunology

SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition

Annika Nelde et al.

Summary: SARS-CoV-2-specific T cell epitopes were identified in convalescent and unexposed individuals, showing cross-reactivity with common cold coronaviruses. The diversity of SARS-CoV-2 T cell responses may be associated with mild symptoms of COVID-19.

NATURE IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19

Lauren B. Rodda et al.

Summary: The study found that individuals recovered from mild COVID-19 develop sustained SARS-CoV-2-specific immunological memory for at least 3 months, including immunoglobulin antibodies, neutralizing plasma, and memory B and T cells. These memory lymphocytes exhibit potent antiviral function, aiding in immune defense.
Article Medicine, Research & Experimental

Recent endemic coronavirus infection is associated with less-severe COVID-19

Manish Sagar et al.

Summary: The study suggests that individuals with prior endemic coronavirus infections were tested more frequently for respiratory infections, but had similar rates of acquiring SARS-CoV-2. Additionally, patients with previous endemic coronavirus infections experienced less severe cases of COVID-19.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Immunology

Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

Alexandra Schafer et al.

Summary: The study shows that combined use of hu-mAbs is effective for prevention and therapy of SARS-CoV-2 infection, but in vivo protection is influenced by intact effector function.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

Article Immunology

Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

Ioanna-Evdokia Galani et al.

Summary: Andreakos and colleagues conducted a study comparing patients with COVID-19 and influenza, finding that COVID-19 patients exhibited a dysregulated interferon response with diminished and delayed interferon production compared to flu patients. In COVID-19 patients, pro-inflammatory cytokines were produced before interferons and persisted longer, leading to worsened clinical outcomes.

NATURE IMMUNOLOGY (2021)

Letter Medicine, General & Internal

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

Alicia T. Widge et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

Article Immunology

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Stuart P. Weisberg et al.

Summary: This study found distinct antibody responses in children and adults after SARS-CoV-2 infection. Adult COVID-19 cohorts showed a broader range of antibody responses, while children predominantly generated antibodies specific for the S protein and had reduced neutralizing activity compared to adults.

NATURE IMMUNOLOGY (2021)

Article Immunology

Cellular Immunity in COVID-19 Convalescents with PCR-Confirmed Infection but with Undetectable SARS-CoV-2-Specific IgG

Sina Schwarzkopf et al.

Summary: The study found that in convalescent patients, immunity against SARS-CoV-2 may be mediated through T cells even in the absence of detectable IgG antibodies.

EMERGING INFECTIOUS DISEASES (2021)

Article Multidisciplinary Sciences

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Daniel Wrapp et al.

SCIENCE (2020)

Article Biochemistry & Molecular Biology

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Daniel Blanco-Melo et al.

Editorial Material Multidisciplinary Sciences

Avoiding pitfalls in the pursuit of a COVID-19 vaccine

Lynne Peeples

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

SARS-CoV-2 infection protects against rechallenge in rhesus macaques

Abishek Chandrashekar et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Development of an inactivated vaccine candidate for SARS-CoV-2

Qiang Gao et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

DNA vaccine protection against SARS-CoV-2 in rhesus macaques

Jingyou Yu et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Virological assessment of hospitalized patients with COVID-2019

Roman Woelfel et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

A serological assay to detect SARS-CoV-2 seroconversion in humans

Fatima Amanat et al.

NATURE MEDICINE (2020)

Article Biochemistry & Molecular Biology

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Mingfeng Liao et al.

NATURE MEDICINE (2020)

Article Biochemistry & Molecular Biology

Temporal dynamics in viral shedding and transmissibility of COVID-19

Xi He et al.

NATURE MEDICINE (2020)

Article Biochemistry & Molecular Biology

Antibody responses to SARS-CoV-2 in patients with COVID-19

Quan-Xin Long et al.

NATURE MEDICINE (2020)

Article Allergy

Two X-linked agammaglobulinemia patients develop pneumonia as COVID-19 manifestation but recover

Annarosa Soresina et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2020)

Review Medicine, General & Internal

Prevalence of Asymptomatic SARS-CoV-2 Infection A Narrative Review

Daniel P. Oran et al.

ANNALS OF INTERNAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity

Qianqian Li et al.

Article Immunology

Distinct Early Serological Signatures Track with SARS-CoV-2 Survival

Caroline Atyeo et al.

IMMUNITY (2020)

Letter Clinical Neurology

Anti-CD20 and COVID-19 in multiple sclerosis and related disorders: A case series of 60 patients from Madrid, Spain

Paloma Montero-Escribano et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2020)

Editorial Material Clinical Neurology

COVID-19 in a MS patient treated with ocrelizumab: does immunosuppression have a protective role?

Giovanni Novi et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2020)

Article Immunology

Comprehensive mapping of immune perturbations associated with severe COVID-19

Leticia Kuri-Cervantes et al.

SCIENCE IMMUNOLOGY (2020)

Article Immunology

SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection

Daniel M. Altmann et al.

SCIENCE IMMUNOLOGY (2020)

Article Medicine, Research & Experimental

Clinical and pathological investigation of patients with severe COVID-19

Shaohua Li et al.

JCI INSIGHT (2020)

Article Biochemistry & Molecular Biology

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

Takuya Sekine et al.

Article Biochemistry & Molecular Biology

The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19

Camila Rosat Consiglio et al.

Article Biochemistry & Molecular Biology

Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19

Benjamin J. Meckiff et al.

Article Biochemistry & Molecular Biology

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

Carolyn Rydyznski Moderbacher et al.

Article Biochemistry & Molecular Biology

Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

Malika Aid et al.

Article Multidisciplinary Sciences

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Julian Braun et al.

NATURE (2020)

Article Multidisciplinary Sciences

Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

Noe B. Mercado et al.

NATURE (2020)

Article Multidisciplinary Sciences

ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

Neeltje van Doremalen et al.

NATURE (2020)

Article Multidisciplinary Sciences

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

Davide F. Robbiani et al.

NATURE (2020)

Article Multidisciplinary Sciences

Longitudinal analyses reveal immunological misfiring in severe COVID-19

Carolina Lucas et al.

NATURE (2020)

Article Multidisciplinary Sciences

Potently neutralizing and protective human antibodies against SARS-CoV-2

Seth J. Zost et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19

Jennifer A. Juno et al.

NATURE MEDICINE (2020)

Article Medicine, General & Internal

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

Kizzmekia S. Corbett et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

An mRNA Vaccine against SARS-CoV-2-Preliminary Report

L. A. Jackson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Immunology

Divergent SARS-CoV-2-specific T- and B-cell responses in severe but not mild COVID-19 patients

Anna E. Oja et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Jerome Hadjadj et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques

Wei Deng et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

Philip J. M. Brouwer et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Broad neutralization of SARS-related viruses by human monoclonal antibodies

Anna Z. Wec et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

Jose Mateus et al.

SCIENCE (2020)

Editorial Material Medicine, General & Internal

COVID-19 and the Path to Immunity

David S. Stephens et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Medicine, Research & Experimental

Kinetics of viral load and antibody response in relation to COVID-19 severity

Yanqun Wang et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Immunology

Antibody Responses to SARS-CoV-2: Let's Stick to Known Knowns

Nicole Baumgarth et al.

JOURNAL OF IMMUNOLOGY (2020)

Review Multidisciplinary Sciences

SARS-CoV-2 vaccines in development

Florian Krammer

NATURE (2020)

Article Multidisciplinary Sciences

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

Ugur Sahin et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

Lisa H. Tostanoski et al.

NATURE MEDICINE (2020)

Article Biochemistry & Molecular Biology

An inflammatory cytokine signature predicts COVID-19 severity and survival

Diane Marie Del Valle et al.

NATURE MEDICINE (2020)

Article Biochemistry & Molecular Biology

A dynamic COVID-19 immune signature includes associations with poor prognosis

Adam G. Laing et al.

NATURE MEDICINE (2020)

Article Biochemistry & Molecular Biology

Seasonal coronavirus protective immunity is short-lasting

Arthur W. D. Edridge et al.

NATURE MEDICINE (2020)

Article Medicine, General & Internal

Humoral Immune Response to SARS-CoV-2 in Iceland

Daniel F. Gudbjartsson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

Edward E. Walsh et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Phase 1-2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine

Cheryl Keech et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Multidisciplinary Sciences

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

Prabhu S. Arunachalam et al.

SCIENCE (2020)

Editorial Material Multidisciplinary Sciences

COVID-19 can affect the heart

Eric J. Topol

SCIENCE (2020)

Article Multidisciplinary Sciences

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Qian Zhang et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Paul Bastard et al.

SCIENCE (2020)

Article Biochemistry & Molecular Biology

Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality

Tomer Zohar et al.

Letter Medicine, General & Internal

Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host

Bina Choi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Multidisciplinary Sciences

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

Yixuan J. Hou et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

Kevin W. Ng et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Robust neutralizing antibodies to SARS-CoV-2 infection persist for months

Ania Wajnberg et al.

SCIENCE (2020)

Article Cell Biology

Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19

Yu Zuo et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Article Immunology

Cross-reactive memory T cells and herd immunity to SARS-CoV-2

Marc Lipsitch et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Cell Biology

Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients

Mehul S. Suthar et al.

CELL REPORTS MEDICINE (2020)

Article Immunology

Tissue-Resident T Cells and Other Resident Leukocytes

David Masopust et al.

Annual Review of Immunology (2019)

Review Biochemistry & Molecular Biology

B Cell Responses: Cell Interaction Dynamics and Decisions

Jason G. Cyster et al.

Review Immunology

Pertussis vaccines and protective immunity

Parul Kapil et al.

CURRENT OPINION IN IMMUNOLOGY (2019)

Review Multidisciplinary Sciences

Immunization: vital progress, unfinished agenda

Peter Piot et al.

NATURE (2019)

Editorial Material Immunology

Back to the Future: Effector Fate during T Cell Exhaustion

Veit R. Buchholz et al.

IMMUNITY (2019)

Review Immunology

Beyond binding: antibody effector functions in infectious diseases

Lenette L. Lu et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Origin and differentiation of human memory CD8 T cells after vaccination

Rama S. Akondy et al.

NATURE (2017)

Article Multidisciplinary Sciences

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

Jesper Pallesen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Editorial Material Multidisciplinary Sciences

Simply put: Vaccination saves lives

Walter A. Orenstein et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Cell Biology

Reduced naive CD8+ T-cell priming efficacy in elderly adults

Olivia Briceno et al.

AGING CELL (2016)

Article Multidisciplinary Sciences

Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting

Katelyn M. Gostic et al.

SCIENCE (2016)

Review Immunology

Interleukin-22: Immunobiology and Pathology

Jarrod A. Dudakov et al.

ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)

Article Multidisciplinary Sciences

Dengue virus infection elicits highly polarized CX3CR1+ cytotoxic CD4+ T cells associated with protective immunity

Daniela Weiskopf et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Immunology

A brief history of T cell help to B cells

Shane Crotty

NATURE REVIEWS IMMUNOLOGY (2015)

Article Immunology

Vaccine-Derived Polioviruses

Cara C. Burns et al.

JOURNAL OF INFECTIOUS DISEASES (2014)

Article Multidisciplinary Sciences

Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model

Jason M. Warfel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Diversity and clonal selection in the human T-cell repertoire

Qian Qi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

Cellular immune correlates of protection against symptomatic pandemic influenza

Saranya Sridhar et al.

NATURE MEDICINE (2013)

Article Medicine, General & Internal

Long-Term Cognitive Impairment after Critical Illness

P. P. Pandharipande et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, General & Internal

Functional Disability 5 Years after Acute Respiratory Distress Syndrome

Margaret S. Herridge et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Multidisciplinary Sciences

Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population

Jason A. Greenbaum et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Duration of antiviral immunity after smallpox vaccination

E Hammarlund et al.

NATURE MEDICINE (2003)