Journal
DERMATOLOGIC THERAPY
Volume 29, Issue 5, Pages 330-333Publisher
WILEY-BLACKWELL
DOI: 10.1111/dth.12369
Keywords
alopecia; hair follicle; therapy-topical
Categories
Funding
- CNPq
- CAPES
- FAP-DF
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There is yet no consensus among prescribers whether minoxidil (MXD) formulations should be applied on wet/damp or dry scalp and no clear FDA guidelines on the matter. We hypothesized that the use of MXD on damp scalp may lead to higher drug penetration. First, because the drug diffusion and consequent deposition into the hair follicle may be favored when follicle cast is humid. Second, because humidity may also prevent drug crystallization and, therefore, maintain a higher thermodynamic activity for longer periods, which leads to increased penetration. Following in vitro experiments on rat and porcine skin we confirmed the hypothesis, which could markedly improve treatment effectiveness.
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