4.3 Article

Efficacy of a Glass Membrane Emulsification Device to Form Mixture of Cisplatin Powder with Lipiodol on Transarterial Therapy for Hepatocellular Carcinoma

Journal

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
Volume 44, Issue 5, Pages 766-773

Publisher

SPRINGER
DOI: 10.1007/s00270-020-02757-2

Keywords

Hepatocellular carcinoma; Arterial embolization; Lipiodol; Emulsion; Cisplatin

Funding

  1. Piolax Medical Devices Co. Ltd.

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The study compared the physiochemical characteristics and drug release properties of cisplatin powder and lipiodol mixtures formed by a glass membrane emulsification device and a 3-way stopcock. The results showed that emulsions formed by the device had a higher percentage of water-in-oil, more homogeneous droplet sizes, and slower cisplatin release compared to those formed by a 3-way stopcock.
Purpose To examine physiochemical characteristics and drug release properties of cisplatin powder and lipiodol mixtures formed by a glass membrane emulsification device compared with a 3-way stopcock. Materials and Methods Seven different types of mixtures were evaluated: cisplatin powder and lipiodol directly mixed (suspension), complete cisplatin solution and lipiodol mixed by a 3-way stopcock or the device (emulsion), incomplete cisplatin solution and lipiodol mixed by a 3-way stopcock or the device (solid-in-water emulsion), and contrast material and cisplatin suspension mixed by a 3-way stopcock or the device (solid-in-oil emulsion). Result The percentages of water-in-oil were 98.08 +/- 0.27% in the emulsion formed by the device, while 70.3 +/- 4.63% in the emulsion formed by a 3-way stopcock (P = 0.037). Solid-in-water and solid-in-oil emulsions formed by the device showed 98.09 +/- 0.38% and 98.70 +/- 0.40% of water-in-oil, respectively, whereas both solid-in-water and solid-in-oil emulsions formed by a 3-way stopcock showed 0.00%. Homogenous droplet sizes were shown by using the device. The half release times of cisplatin in the emulsions formed by the device were 197 +/- 19, 244 +/- 24 and 478 +/- 52 min, respectively, which were significantly longer than the emulsion formed by a 3-way stopcock of 8 +/- 8 min (P = 0.046-0.050). Suspension showed the longest release time; however, the viscosity was lowest. Conclusion The glass membrane emulsification device formed almost 100% water-in-oil, whereas 3-way stopcock produced 100% oil-in-water when incomplete solution or suspension was mixed. Slower cisplatin release was shown in the emulsions formed by the device.

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