Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

BACKGROUNDPlatelet-rich plasma (PRP) was identified as having a beneficial effect in alopecia and has been postulated as a new therapy for androgenetic alopecia (AGA).OBJECTIVETo assess the efficacy of PRP for the treatment of AGA.MATERIALS AND METHODSThis was a randomized, placebo-controlled, double-blind study in 25 patients with AGA. Platelet-rich plasma was injected in half-head and the other half-head with placebo. Each patient received a total of 3 treatments of PRP, 1 month apart.RESULTSSix months after the first treatment with PRP, significant differences were seen in mean anagen hairs (67.6 13.1), telogen hairs (32.4 +/- 13.1), hair density (179.9 +/- 62.7), and terminal hair density (165.8 +/- 56.8) when compared with baseline (p < .05). Platelet-rich plasma was also found to increase hair density when comparing with the control side (p < .05). For the first time, the authors found a correlation between anagen hairs and patients >40 years and beginning of AGA 25 years old (p < .05) and hair density and male sex, age 40 years, positive family history of AGA and >10 years of duration of the disease (p < 0.05).CONCLUSIONApplication of PRP showed a positive effect on AGA and could be regarded as an adjuvant therapy for AGA.