4.5 Article

Efficient selective deacetylation of complex oligosaccharides using the neutral organotin catalyst [tBu2SnOH(Cl)]2

Journal

CARBOHYDRATE RESEARCH
Volume 498, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2020.108172

Keywords

Selective deacetylation; Tetra-tert-butyl-3-chloro-1-hydroxydistannoxane

Funding

  1. G. Ronzoni foundation

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Tetra-tert-butyl-3-chloro-1-hydroxydistannoxane has been found to selectively cleave with high efficiency primary acetates on complex oligosaccharides containing esterified L-iduronic acid and bearing an anomeric acetate. This tin based catalyst was found much more effective than magnesium methoxide to carry out selective deacetylation.

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