Journal
CARBOHYDRATE POLYMERS
Volume 250, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.116970
Keywords
Curcumin-zein nanoparticles; Chondroitin sulfate; Ultrasounanti-solvent method; Morphology; pH
Categories
Funding
- National Natural Science Foundation of China [31801536]
- Key Research and Development Program of Zhejiang province [2019C02070, 2018C02012, 2020C02042, 2020C02046]
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This study is aiming to investigate the stabilizing effect of chondroitin sulfate (CS) on the preparation of curcumin nanoparticles (NPs). The results showed that adding CS before the anti-solvent process of zein (Z) at pH7 could fabricate most stable NPs (Cur/CS/Z-pH7) with particle size of 197 +/- 5 nm and zeta-potential of -48.4 +/- 1.9 mV. The pH had a significant effect on the fabrication of NPs. Cur/CS/Z-pH7 was more stable than Cur/CS/Z-pH3, while Cur/Z-CS-pH3 was more stable than the Cur/Z-CS-pH7. According to the results of XRD, FTIR, DSC and CD, CS can form irreversible macromolecular complexes with zein through non-electrostatic interactions during the anti-solvent process (Cur/CS/Z-pH7, Cur/CS/Z-pH3). However, CS was adsorbed on the surface of Zein NPs by electrostatic interaction (Cur/Z-CS-pH7, Cur/Z-CS-pH3), when CS was added after anti-solvent process of zein. These results illustrated that it is better to add CS before the anti-solvent process of zein at neutral pH.
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