Journal
CARBOHYDRATE POLYMERS
Volume 252, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.117145
Keywords
Chitooligosaccharide-salicylic acid conjugate; Gelatin; Oxidized alginate; Schiff's base reaction; Wound healing
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Funding
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2019R1A2C1007218]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2019R1A6A3A13092749]
- National Research Foundation of Korea [2019R1A6A3A13092749, 2019R1A2C1007218] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In this study, chitooligosaccharide (COS) and salicylic acid (SA) conjugates were synthesized and oxidized alginate (OA) and gelatin hydrogels were fabricated. Tests confirmed successful synthesis of COS-SA conjugates with improved antioxidant activity. The hydrogels showed non-cytotoxicity and wound healing activity, indicating their potential for wound healing applications.
In the present study, chitooligosaccharide (COS) and salicylic acid (SA) conjugates were synthesized using H2O2-induced grafting polymerization and oxidized alginate (OA) and gelatin hydrogels were fabricated using Schiff's base reaction. To confirm the synthesis and improved activity of the COS-SA conjugates, polyphenol assays, ultraviolet absorbance, NMR, and antioxidant activity tests were all conducted. The results showed that the COS-SA conjugates were completely synthesized and improved antioxidant activity. OA was synthesized using a periodate method and a hydrogel was obtained at a mixed ratio of 3:7 via crosslinking between the aldehyde group of the OA and the amine groups of gelatin with COS-SA conjugates. In a cytotoxicity and wound healing model, the hydrogels with COS-SA conjugates did not exhibit cytotoxicity and exhibited wound healing activity in a mouse model. These results provide evidence that OA and gelatin hydrogels with a COS-SA conjugate can be successfully used for wound healing applications.
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