Journal
CARBOHYDRATE POLYMERS
Volume 251, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.117125
Keywords
Selenium nanoparticles; Tragacanth Gum; Antibacterial activity; Antioxidant activity; Wound-healing assay
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SeNPs/TG showed relatively narrow size distribution compared to Se NPs, indicating successful synthesis of selenium nanoparticles. The combination of TG with Se NPs resulted in a stabilized solution with enhanced antioxidant activity. While the Se NPs and SeNPs/TG solutions exhibited significant inhibition against bacteria, the treated nanofibers did not show significant antibacterial activity, but did promote fibroblast cell migration in wound healing applications.
Polysaccharide-based nanofibers from Tragacanth Gum (TG) and polyethylene terephthalate (PET) were post-treated with selenium nanoparticles (Se NPs) and also stabilized with TG (SeNPs/TG). DLS, FE-SEM, EDX, TEM, and XRD were employed to verify the synthesis of Se NPs. The relatively narrow size distribution of SeNPs/TG showed through TEM and DLS investigations comparing with Se NPs. The Se NPs formation with and without TG was studied with FTIR confirmed the final stabilized solution due to the bonded hydroxyl groups of TG with Se NPs. Also, a relatively higher antioxidant reported on SeNPs/TG at 0.5-5 mg/mL using DPPH scavenging ability. The Se NPs and SeNPs/TG solutions specified remarkable inhibition against Staphylococcus aureus and Candida albicans; however, no significant antibacterial activities observed on the treated nanofibers. Finally, the uniform migration of fibroblast cells in wound healing of the treated nanofibers with SeNPs/TG proved the value of the products in medical applications.
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