Journal
CARBOHYDRATE POLYMERS
Volume 249, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.116847
Keywords
Carboxymethyl chitosan; Heterocyclic compounds; Antifungal activity; Antioxidant activity; Cytotoxicity assay
Categories
Funding
- National Key R&D Program of China [2019YFD0900705]
- Key R&D Program of Shandong Province [2019GHY112010, 2018YYSP027]
- Natural Science Foundation of Shandong Province of China [ZR2019BD064]
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In this paper, several novel chitosan derivatives bearing benzenoid / heterocyclic moieties were synthesized via introducing aminobenzene and heterocyclic compounds onto carboxymethyl chitosan. The specific structures of chitosan derivatives were confirmed by FTIR, H-1 NMR, and elemental analysis. Meanwhile, the antioxidant efficiencies of chitosan derivatives were assayed in vitro. In particular, all chitosan derivatives showed significant improvement in superoxide-radical scavenging activity and DPPH radical scavenging activity. Their antifungal activities against two plant pathogenic fungi (Colletotrichum lagenarium and Phomopsis asparagi) were estimated in vitro by hyphal measurement, and all products exhibited excellent antifungal activity. Besides, the cytotoxicity of them was also measured by CCK-8 in vitro on L929 cells, and all samples showed low cytotoxicity. The good biocompatibility and enhanced biological activity of new synthetic chitosan derivatives might be obvious ad-vantages, while applied in wide range of applications as antifungal agents or antioxidants in food, medicine, cosmetics, and other fields.
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