Journal
CANCER SCIENCE
Volume 112, Issue 2, Pages 505-514Publisher
WILEY
DOI: 10.1111/cas.14747
Keywords
anti‐ cancer drug; cancer; Drosophila; genetics; whole‐ body platform
Categories
Funding
- Joint Usage/Research Center for Genetic Medicine, Hokkaido University
- Photo-excitonix Project in Hokkaido University
- MEXT/JSPS KAKENHI [19H05412, 19K22478, 20H03524, 20K07558]
- AMED [JP20ck0106548, JP20cm0106273]
- AMED (Translational Research program)
- AMED (Strategic PRomotion for practical application of INnovative medical Technology (TR-SPRINT))
- MSD Life Science Foundation
- SGH Foundation
- Foundation for Promotion of Cancer Research in Japan
- Project Mirai Cancer Research Grants
- Ichiro Kanehara Foundation
- Princess Takamatsu Cancer Research Fund
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Suhara Memorial Foundation
- Tokyo Biochemical Research Foundation
- Japan Foundation for Applied Enzymology
- Takeda Science Foundation
- Suzuken Memorial Foundation
- Akiyama Life Science Foundation
- All Japan Coffee Association
- Pharmacological Research Foundation, Tokyo
- Grants-in-Aid for Scientific Research [19K22478, 19H05412, 20K07558, 20H03524] Funding Source: KAKEN
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The fruit fly Drosophila has played a crucial role in advancing cancer research by providing insights into fundamental mechanisms of cancer development, such as loss of cell polarity. In recent years, scalable Drosophila platforms have proved useful in developing effective anti-cancer regimens for both mammalian models and patients.
Cancer burden has been increasing worldwide, making cancer the second leading cause of death in the world. Over the past decades, various experimental models have provided important insights into the nature of cancer. Among them, the fruit fly Drosophila as a whole-animal toolkit has made a decisive contribution to our understanding of fundamental mechanisms of cancer development including loss of cell polarity. In recent years, scalable Drosophila platforms have proven useful also in developing anti-cancer regimens that are effective not only in mammalian models but also in patients. Here, we review studies using Drosophila as a tool to advance cancer study by complementing other traditional research systems.
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