Journal
CANCER LETTERS
Volume 496, Issue -, Pages 30-40Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2020.09.020
Keywords
Mechanotransduction; RNA binding Proteins; Transcriptional regulation; Noncoding RNAs; Ribonucleocomplex; Metastasis
Categories
Funding
- National Key Research and Development Program of China [2017YFA0104801]
- China Postdoctoral Science Foundation [2020M673209]
- Postdoctoral Fellowship of Sichuan University [2020SCU12060]
- One Thousand Talents program from the Chinese Central Government
- One Thousand Talents program from the Sichuan Province
- Fundamental Research Funds for the Central Universities [SCU2019D013]
- National Natural Science Foundation of China [82002650]
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Mechanotransduction is a crucial cellular process involving the response to mechanical signals, which is associated with various physiological conditions and diseases such as cancer. Recent studies have highlighted the significant role of RNA binding proteins in mechanotransduction and cancer metastasis.
Mechanotransduction is the leading cellular process that mammalian cells adopted to receive and respond to various mechanical cues from their local microenvironment. Increasing evidence suggests that mechano-transduction is involved in many physiological and disease conditions, ranging from early embryonic development, organogenesis, to a variety of human diseases including cancer. Mechanotransduction is mediated through several classes of senor proteins on the cell surface, intracellular signaling mediators, and core transcriptional regulation networks. Dissecting the molecular mechanisms regulating mechanotransduction and their association with cancer metastasis has received much attention in recent years. RNA binding proteins (RBPs) are a special group of nucleic acid interacting factors that participate in many important cellular processes. In this review, we would like to summarize recent research progresses in understanding the role of RBPs-mediated regulation in mechanotransduction and cancer metastasis. Those intriguing findings will provide novel insights for the disease and guide the potential development of new therapeutic approaches.
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