Journal
CANCER CELL INTERNATIONAL
Volume 20, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12935-020-01679-w
Keywords
RNA methylation; m6A; m6Am; m1A; m5C; Gastrointestinal cancers
Categories
Funding
- Natural Scientific Foundation of China [31620103911, 31571446]
- Young Scientists Fund [31801132]
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RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression, particularly in gastrointestinal cancers. RNA methylation has a variety of biological properties, including N6-methyladenosine (m6A), 2-O-dimethyladenosine (m6Am), N1-methyladenosine (m1A), 5-methylcytosine (m5C) and 7-methyl guanosine (m7G). Dynamic and reversible methylation on RNA is mediated by RNA modifying proteins called writers (methyltransferases) and erasers (demethylases). Readers (modified RNA binding proteins) recognize and bind to RNA methylation sites, which influence the splicing, stability or translation of modified RNAs. Herein, we summarize the biological functions and mechanisms of these well-known RNA methylations, especially focusing on the roles of m6A in gastrointestinal cancer development.
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