Journal
DERMATOLOGIC CLINICS
Volume 34, Issue 1, Pages 51-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.det.2015.08.004
Keywords
Hidradenitis suppurativa; Inflammation; Immunology; Pathogenesis; Cytokines
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Hidradenitis suppurativa (HS) is a chronic relapsing disease of follicular occlusion that causes immense clinical and psychosocial morbidity when refractory to treatment. HS is no longer considered a disease of primary infectious etiology, although bacteria play a role. There is increasing evidence that HS is associated with immune dysregulation, based on its clinical association with other immune-mediated disorders, by its response to biologic therapy in the clinical arena, and from molecular research. This article summarizes what is known in relation to the inflammatory pathways in HS.
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