Efficient Continuous-Flow H-D Exchange Reaction of Aromatic Nuclei in D2O/2-PrOH Mixed Solvent in a Catalyst Cartridge Packed with Platinum on Carbon Beads

Herein, a continuous-flow deuteration methodology for various aromatic compounds is developed based on heterogeneous platinum-catalyzed hydrogen-deuterium exchange. The reaction entails the transfer of a substrate dissolved in a mixed solvent of 2-propanol and deuterium oxide into a catalyst cartridge packed with platinum on carbon beads (Pt/CB). Pt/CB could be continuously used without significant deterioration of catalyst activity for at least 24 h. Deuteration proceeded within 60s of the substrate solutions being passed through the Pt/CB layer in the Pt/CB-packed cartridge.

Automated summary

A continuous-flow deuteration methodology for various aromatic compounds is developed based on heterogeneous platinum-catalyzed hydrogen-deuterium exchange. The use of Pt/CB as catalyst support allows for continuous operation for at least 24 hours without significant deterioration of catalyst activity. Deuteration of substrate solutions through the Pt/CB layer in the cartridge packed with Pt/CB can be completed within 60 seconds.