Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 192, Issue 3, Pages 621-625Publisher
WILEY
DOI: 10.1111/bjh.17249
Keywords
haemophilia A; inhibitor; IgG subclasses; predictive biomarkers
Categories
Funding
- Aspire Pfizer grant [N WI212576]
- Novo Nordisk Changing Possibilities in Haemophilia Italian Academy grant
- CSL Behring
- Italian Ministry of Health, Bando Ricerca Corrente
- Prof. Heimburger Award
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Risk of inhibitor persistence increased with the concomitant presence of an increasing number of IgG subclasses within the first 60 days post inhibitor detection, while only the IgG2 subclass could be considered a hallmark of inhibitor persistence over the 6-month period post inhibitor detection.
We investigated longitudinally the behaviour of anti-factor VIII (anti-FVIII) IgG subclasses for 6 months from inhibitor development in 43 patients from the Survey of Inhibitors in Plasma-Products Exposed Toddlers (SIPPET) trial who developed persistent or transient inhibitors. We first analysed 43 patients within 60 days post inhibitor detection. Then, 14 of these 43 patients were studied at five time points over 6 months. Our study showed that during the first 60 days, the risk of inhibitor persistence increased with the concomitant presence of an increasing number of IgG subclasses. Over the 6-month period post inhibitor detection, only the IgG2 subclass could be considered a hallmark of inhibitor persistence.
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