Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 193, Issue 4, Pages 841-844Publisher
WILEY
DOI: 10.1111/bjh.17316
Keywords
molecular; clonality; stem cell mobilization; homing; haematopoietic stem cells
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Clonal hematopoiesis of indeterminant potential (CHIP) increases with age and may affect the mobilization of autologous CD34+ peripheral blood stem cells. This study shows that somatic mutations in certain genes can predict poor mobilization of CD34+ PBSC, potentially reducing mobilization and graft failures.
Clonal haematopoiesis of indeterminant potential (CHIP) increases in frequency with age. The effect of CHIP on the mobilization of autologous CD34+ peripheral blood stem cells (PBSC) has not been reported. This study uses a DNA-based targeted candidate gene approach to identify the presence of somatic mutations in ASXL1, DNMT3A, JAK2, SF3B1, TET2 and TP53 in CD34+ haematopoietic progenitor cell-apheresis products of 96 patients who undergo PBSC mobilization for autologous stem cell transplantation (ASCT). Variants were identified in a significantly greater proportion of patients who experience poor CD34+ PBSC mobilization. A DNA-based targeted candidate gene array is able to predict poor CD34+ PBSC mobilization and may be deployed pre-emptively to minimize mobilization and graft failures.
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