Bioinformatics resources for SARS-CoV-2 discovery and surveillance

In early January 2020, the novel coronavirus (SARS-CoV-2) responsible for a pneumonia outbreak in Wuhan, China, was identified using next-generation sequencing (NGS) and readily available bioinformatics pipelines. In addition to virus discovery, these NGS technologies and bioinformatics resources are currently being employed for ongoing genomic surveillance of SARS-CoV-2 worldwide, tracking its spread, evolution and patterns of variation on a global scale. In this review, we summarize the bioinformatics resources used for the discovery and surveillance of SARS-CoV-2. We also discuss the advantages and disadvantages of these bioinformatics resources and highlight areas where additional technical developments are urgently needed. Solutions to these problems will be beneficial not only to the prevention and control of the current COVID-19 pandemic but also to infectious disease outbreaks of the future.

Automated summary

In early 2020, the novel coronavirus responsible for the pneumonia outbreak in Wuhan was identified using NGS and bioinformatics pipelines. These technologies are now being used globally for genomic surveillance of SARS-CoV-2, tracking its spread, evolution, and global variation patterns, with a focus on technical advancements needed for future infectious disease outbreaks.