Journal
BRAIN
Volume 144, Issue 2, Pages 504-514Publisher
OXFORD UNIV PRESS
DOI: 10.1093/brain/awaa407
Keywords
Parkinson's disease; freezing of gait; antisaccade; oculomotor recording
Categories
Funding
- ANR Nucleipark
- DHOS-Inserm
- France Parkinson
- Ecole des NeuroSciences de Paris (ENP)
- Fondation pour la Recherche Medicale (FRM)
- Investissements d'Avenir, IAIHU-06 (Paris Institute of Neurosciences - IHU) [ANR-11-INBS-0006]
- Fondation d'Entreprise EDF
- Biogen Inc.
- Fondation Therese and Rene Planiol
- Societe Francaise de Medecine Esthetique
Ask authors/readers for more resources
Freezing of gait in Parkinson's disease is associated with increased antisaccade latencies, which predict the onset of freezing within 5 years. Patients who developed freezing during the follow-up had longer antisaccade latencies compared to those who did not. Resting state connectivity of mesencephalic locomotor region networks was differentially associated with antisaccade latency in patients at baseline and contributed to the further increase in latency over 5 years.
Freezing of gait is a challenging sign of Parkinson's disease associated with disease severity and progression and involving the mesencephalic locomotor region. No predictive factor of freezing has been reported so far. The primary objective of this study was to identify predictors of freezing occurrence at 5 years. In addition, we tested whether functional connectivity of the mesencephalic locomotor region could explain the oculomotor factors at baseline that were predictive of freezing onset. We performed a prospective study investigating markers (parkinsonian signs, cognitive status and oculomotor recordings, with a particular focus on the antisaccade latencies) of disease progression at baseline and at 5 years. We identified two groups of patients defined by the onset of freezing at 5 years of follow-up; the 'Freezer' group was defined by the onset of freezing in the ON medication condition during follow-up (n = 17), while the 'non-Freezer' group did not (n = 8). Whole brain resting-state functional MRI was recorded at baseline to determine how antisaccade latencies were associated with connectivity of the mesencephalic locomotor region networks in patients compared to 25 age-matched healthy volunteers. Results showed that, at baseline and compared to the non-Freezer group, the Freezer group had equivalent motor or cognitive signs, but increased antisaccade latencies (P = 0.008). The 5-year course of freezing of gait was correlated with worsening antisaccade latencies (P = 0.0007). Baseline antisaccade latencies was also predictive of the freezing onset (chi(2) = 0.008). Resting state connectivity of mesencephalic locomotor region networks correlated with (i) antisaccade latency differently in patients and healthy volunteers at baseline; and (ii) the further increase of antisaccade latency at 5 years. We concluded that antisaccade latency is a predictive marker of the 5-year onset of freezing of gait. Our study suggests that functional networks associated with gait and gaze control are concurrently altered during the course of the disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available