Journal
BMC MUSCULOSKELETAL DISORDERS
Volume 22, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12891-021-03954-x
Keywords
Primary hyperparathyroidism; Distal renal tubule; Acidification function; Bone mineral density
Categories
Ask authors/readers for more resources
Our study found that about 54.6% of PHPT patients had abnormal distal renal tubular acidification. This may lead to lower hip bone density. Female PHPT patients with abnormal distal renal tubular acidification are more susceptible to fractures and osteoporosis.
BackgroundPrimary hyperparathyroidism (PHPT) is a common endocrinopathy that may increase fracture risk and decrease bone mineral density (BMD). Some patients develop distal renal tubular acidification dysfunction under conditions of hyperchloraemia or hyperchloraemic acidosis. To examine whether this dysfunction influences the clinical outcome, we explored the distal renal tubular acidification function in patients with PHPT and its effects on the clinical manifestations of the disease.MethodsWe retrospectively analysed 75 PHPT patients with regard to renal tubular acidification and blood gas analysis. The patients were divided into two groups, the renal tubular acidification dysfunction group and normal function group.ResultsSerum phosphate level and total hip bone density were significantly decreased and 25OHD level was significantly increased in the renal tubular acidification dysfunction group in comparison to the normal function group. Female patients in the renal tubular acidification dysfunction group showed significantly decreased femoral neck and total hip BMD and increased susceptibility to fracture. However, there were no such differences in male patients between the two groups.ConclusionsAbout 54.6% of PHPT patients in our study population had abnormal distal renal tubular acidification. PHPT patients with abnormal distal renal tubular acidification may have lower hip bone density. Female PHPT patients with abnormal distal renal tubular acidification showed increased susceptibility to fractures and the development of osteoporosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available