4.5 Article

Dynamic changes in lymphocyte subsets and parallel cytokine levels in patients with severe and critical COVID-19

Related references

Note: Only part of the references are listed.
Article Immunology

Longitudinal Profile of Laboratory Parameters and Their Application in the Prediction for Fatal Outcome Among Patients Infected With SARS-CoV-2: A Retrospective Cohort Study

Hao-Long Zeng et al.

Summary: The study conducted a retrospective cohort study on 642 patients with COVID-19 in a designated hospital in Wuhan, China, determining 3 clinical stages and analyzing laboratory parameters and cytokines at each stage. The findings indicate that factors such as age, lactate dehydrogenase, procalcitonin, lymphocyte count, and interleukin 6 play crucial roles in predicting fatal outcomes for COVID-19 patients.

CLINICAL INFECTIOUS DISEASES (2021)

Article Medicine, General & Internal

Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia A Randomized Clinical Trial

Olivier Hermine et al.

Summary: In this clinical trial of COVID-19 patients with pneumonia requiring oxygen support but not in the ICU, tocilizumab did not reduce WHO-CPS scores below 5 by day 4 but may have reduced the risk of needing noninvasive ventilation, mechanical ventilation, or death by day 14. There was no difference in mortality by day 28. Further studies are needed to confirm these preliminary results.

JAMA INTERNAL MEDICINE (2021)

Article Medicine, General & Internal

Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia A Randomized Clinical Trial

Carlo Salvarani et al.

Summary: This study evaluated the use of tocilizumab in hospitalized COVID-19 pneumonia patients and found no significant benefit compared to standard care. Further randomized clinical trials with blinded, placebo-controlled methods are needed to confirm these results and explore potential applications of tocilizumab in different stages of the disease.

JAMA INTERNAL MEDICINE (2021)

Article Immunology

Systematic Examination of Antigen-Specific Recall T Cell Responses to SARS-CoV-2 versus Influenza Virus Reveals a Distinct Inflammatory Profile

Jaclyn C. Law et al.

Summary: This study investigated T cell responses to SARS-CoV-2 in early convalescent individuals and found that while all subjects showed at least one specific T cell response, the responses were less multifunctional in severe cases compared to influenza-specific responses. CD4(+) Th1 responses predominated over CD8(+) T cell responses, had a more inflammatory profile, and showed weaker pTfh responses to SARS-CoV-2 compared to influenza virus within the same donors, potentially contributing to COVID-19 disease.

JOURNAL OF IMMUNOLOGY (2021)

Article Medicine, General & Internal

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China

Dawei Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

Letter Immunology

Fatal COVID-19 infections: Is NK cell dysfunction a link with autoimmune HLH?

Mohammed S. Osman et al.

AUTOIMMUNITY REVIEWS (2020)

Article Microbiology

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

Evangelos J. Giamarellos-Bourboulis et al.

CELL HOST & MICROBE (2020)

Article Microbiology

A Dynamic Immune Response Shapes COVID-19 Progression

Eugenia Ziying Ong et al.

CELL HOST & MICROBE (2020)

Article Medicine, General & Internal

Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7)

Pei-Fang Wei

CHINESE MEDICAL JOURNAL (2020)

Article Critical Care Medicine

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

Zhe Xu et al.

LANCET RESPIRATORY MEDICINE (2020)

Article Medicine, Research & Experimental

Clinical and immunological features of severe and moderate coronavirus disease 2019

Guang Chen et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Immunology

Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia

Fan Wang et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

Editorial Material Multidisciplinary Sciences

Cytokine release syndrome in severe COVID-19

John B. Moore et al.

SCIENCE (2020)

Article Medicine, General & Internal

Regulatory T Cells Modulate CD4 Proliferation after Severe Trauma via IL-10

Ramona Sturm et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Immunology

SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection

Daniel M. Altmann et al.

SCIENCE IMMUNOLOGY (2020)

Article Infectious Diseases

Dynamic changes in peripheral blood lymphocyte subsets in adult patients with COVID-19

Zhifeng Deng et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

Letter Infectious Diseases

The dilemma of COVID-19 recurrence after clinical recovery

Marco Bongiovanni et al.

JOURNAL OF INFECTION (2020)

Article Medicine, General & Internal

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19

John H. Stone et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Immunology

Cytokine storm and sepsis disease pathogenesis

Benjamin G. Chousterman et al.

SEMINARS IN IMMUNOPATHOLOGY (2017)

Article Hematology

IL-6 blocks a discrete early step in lymphopoiesis

K Maeda et al.

BLOOD (2005)