Journal
BMC GENOMICS
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12864-020-07294-3
Keywords
Bisphenol S; Perinatal and chronic exposure; Liver; DNA methylation; Transcriptome
Funding
- Endocrine Disruptor National Research Program - Ministere de la transition ecologique et solidaire
- Ministere de l'Enseignement Superieur et de la Recherche
- AgrosupDijon (France)
Ask authors/readers for more resources
BackgroundBisphenol S (BPS) is a common bisphenol A (BPA) substitute, since BPA is virtually banned worldwide. However, BPS and BPA have both endocrine disrupting properties. Their effects appear mostly in adulthood following perinatal exposures. The objective of the present study was to investigate the impact of perinatal and chronic exposure to BPS at the low dose of 1.5 mu g/kg body weight/day on the transcriptome and methylome of the liver in 23weeks-old C57BL6/J male mice.ResultsThis multi-omic study highlights a major impact of BPS on gene expression (374 significant deregulated genes) and Gene Set Enrichment Analysis show an enrichment focused on several biological pathways related to metabolic liver regulation. BPS exposure also induces a hypomethylation in 58.5% of the differentially methylated regions (DMR). Systematic connections were not found between gene expression and methylation profile excepted for 18 genes, including 4 genes involved in lipid metabolism pathways (Fasn, Hmgcr, Elovl6, Lpin1), which were downregulated and featured differentially methylated CpGs in their exons or introns.ConclusionsThis descriptive study shows an impact of BPS on biological pathways mainly related to an integrative disruption of metabolism (energy metabolism, detoxification, protein and steroid metabolism) and, like most high-throughput studies, contributes to the identification of potential exposure biomarkers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available