Remodel your way to fetal hematopoiesis

In this issue of Blood, the study by Ding et al(1) describes a novel role for the chromatin remodeling factor smarca(5) during the development of hematopoietic stem and progenitor cells (HSPCs) as they emerge from dorsal aorta hemogenic endothelium(2-4) and then transition to fetal-like stage.(5,6)

Automated summary

The study reveals a novel role of the chromatin remodeling factor Smarca during the development of HSPCs, as they emerge from the dorsal aorta hemogenic endothelium and transition to a fetal-like stage.