Journal
BLOOD
Volume 137, Issue 13, Pages 1713-1718Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood.2020008188
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Funding
- Dutch Cancer Society
- China Scholarship Council
- LymphCo
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Plasma cells in multiple myeloma rely heavily on communication with the bone marrow microenvironment for survival, with specific growth and survival factors being regulated by syndecan-1/HSPGs and their synthesis machinery.
Plasma cells no longer express a B-cell antigen receptor and are hence deprived of signals crucial for survival throughout B-cell development. Instead, normal plasma cells, aswell as their malignantmyelomacounterparts, heavily rely on communication with the bone marrow (BM) microenvironment for survival. The plasma cell heparan sulfate proteoglycan (HSPG) syndecan-1 (CD138) and HSPGs in the BM microenvironment act as master regulators of this communication by co-opting specific growth and survival factors from the BM niche. This designates syndecan-1/HSPGs and their synthesis machinery as potential treatment targets in multiple myeloma.
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