4.3 Article

Computational drug repurposing study of the RNA binding domain of SARS-CoV-2 nucleocapsid protein with antiviral agents

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Structure prediction of eukaryotic elongation factor-2 kinase and identification of the binding mechanisms of its inhibitors: homology modeling, molecular docking, and molecular dynamics simulation

Gizem Tatar et al.

Summary: Protein kinases are successful drug targets, and eEF-2K has been identified as a potential therapeutic target for certain aggressive solid cancers. This study used modeling, docking analysis, and molecular dynamics simulations to understand the binding mechanism of eEF-2K with inhibitors, providing insights for the development of new selective and potential eEF-2K inhibitors.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

Article Biochemistry & Molecular Biology

Repurposing drugs for treatment of SARS-CoV-2 infection: computational design insights into mechanisms of action

Shubhangi Kandwal et al.

Summary: The COVID-19 pandemic has had a negative impact on global human life, causing economic crises and health emergencies. In this study, computational drug design technologies were used to repurpose existing drugs as inhibitors of SARS-CoV-2 viral proteins. The results may help accelerate drug development against COVID-19 and have significant implications.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

Article Biochemistry & Molecular Biology

Screening of Chloroquine, Hydroxychloroquine and its derivatives for their binding affinity to multiple SARS-CoV-2 protein drug targets

Mallikarjuna Nimgampalle et al.

Summary: The research aims to investigate the therapeutic potential of Chloroquine and its derivatives against SARS-CoV-2 viral proteins, showing that these compounds can bind to viral proteins and disrupt their active sites.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Editorial Material Biotechnology & Applied Microbiology

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

Guangdi Li et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Editorial Material Medicine, General & Internal

Another Decade, Another Coronavirus

Stanley Perlman

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

A Novel Coronavirus from Patients with Pneumonia in China, 2019

Na Zhu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Biochemistry & Molecular Biology

COVID19 inhibitors: A prospective therapeutics

Md Jawaid Akhtar

BIOORGANIC CHEMISTRY (2020)

Review Public, Environmental & Occupational Health

SARS-CoV-2 jumping the species barrier: Zoonotic lessons from SARS, MERS and recent advances to combat this pandemic virus

Kuldeep Dhama et al.

TRAVEL MEDICINE AND INFECTIOUS DISEASE (2020)

Article Biochemistry & Molecular Biology

Improvements to the APBS biomolecular solvation software suite

Elizabeth Jurrus et al.

PROTEIN SCIENCE (2018)

Review Pharmacology & Pharmacy

Drug repurposing screens and synergistic drug-combinations for infectious diseases

Wei Zheng et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Article Gastroenterology & Hepatology

Geographic distribution and characteristics of genotype A hepatitis B virus infection in acute and chronic hepatitis B patients in Japan

Kiyoaki Ito et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2016)

Article Pharmacology & Pharmacy

Protease inhibitors targeting coronavirus and filovirus entry

Yanchen Zhou et al.

ANTIVIRAL RESEARCH (2015)

Review Virology

The Coronavirus Nucleocapsid Is a Multifunctional Protein

Ruth McBride et al.

VIRUSES-BASEL (2014)

Article Biochemistry & Molecular Biology

Crystal structure-based exploration of the important role of Arg106 in the RNA-binding domain of human coronavirus OC43 nucleocapsid protein

I. -Jung Chen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2013)

Article Chemistry, Medicinal

Drug Repurposing in Chemical Genomics: Can We Learn from the Past to Improve the Future?

William H. Bisson

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2012)

Article Chemistry, Multidisciplinary

AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility

Garrett M. Morris et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Coronavirus N Protein N-Terminal Domain (NTD) Specifically Binds the Transcriptional Regulatory Sequence (TRS) and Melts TRS-cTRS RNA Duplexes

Nicholas E. Grossoehme et al.

JOURNAL OF MOLECULAR BIOLOGY (2009)

Review Microbiology

Coronaviruses post-SARS: update on replication and pathogenesis

Stanley Perlman et al.

NATURE REVIEWS MICROBIOLOGY (2009)

Article Virology

Genetic diversity in the yellow head nidovirus complex

Priyanjalie K. M. Wijegoonawardane et al.

VIROLOGY (2008)

Article Virology

Coronavirus nucleocapsid protein is an RNA chaperone

Sonia Zuniga et al.

VIROLOGY (2007)

Review Virology

A contemporary view of coronavirus transcription

Stanley G. Sawicki et al.

JOURNAL OF VIROLOGY (2007)

Article Biotechnology & Applied Microbiology

Mechanisms and enzymes involved in SARS coronavirus genome expression

V Thiel et al.

JOURNAL OF GENERAL VIROLOGY (2003)

Review Biotechnology & Applied Microbiology

Virus-encoded proteinases and proteolytic processing in the Nidovirales

J Ziebuhr et al.

JOURNAL OF GENERAL VIROLOGY (2000)