Journal
BIOTECHNOLOGY PROGRESS
Volume 37, Issue 3, Pages -Publisher
WILEY
DOI: 10.1002/btpr.3130
Keywords
cell culture media; filtration; fouling model; particle size distribution; sterile
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This study evaluated the impact of different sterile filters on CHO cell culture media and discussed the key particle size range for optimal filter performance by measuring the submicron order particle size distribution. Understanding the media particle counts and size distribution may help predict the performance of filter capacity with size-exclusive separation.
Cell culture media used in CHO-based biologic processes are typically sterile filtered to prevent microbial contamination prior to inoculation. In this study, the impact of common sterile filter throughput on a different, commercially available cell culture media was evaluated from the intermediate-adsorption fouling model of the filtration model. The key particle size range for optimum filter performance was discussed and identified by measuring the submicron order particle size distribution. It may be possible to predict the performance of filter capacity with size-exclusive separation by understanding the media particle counts and size distribution.
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