Journal
BIOSCIENCE REPORTS
Volume 41, Issue 2, Pages -Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BSR20203584
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Funding
- National Natural Science Foundation of China [82070807, 91749118, 81770775, 81730022]
- Planned Science and Technology Project of Hunan Province [2017RS3015]
- National Key Research and Development Program [2019YFA0801903, 2018YFC2000100]
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This meta-analysis investigated the association between hyperglycemia at admission and COVID-19 outcomes, and found that hyperglycemia at admission may be a strong predictor of mortality and complications in COVID-19 patients.
Background: Hyperglycemia at admission has been demonstrated to exacerbate the outcomes of coronavirus disease 2019 (COVID-19) but a meta-analysis is lacking to further confirm this hypothesis. The purpose of this meta-analysis was to summarize the evidence on the association between hyperglycemia at admission and the development of COVID-19. Method: Four databases namely, PubMed, Web of Science, Embase and Cochrane Library, were screened for eligible studies. STATA software was utilized to pool data for this meta-analysis. The primary outcomes included mortality and severity. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with random-effects models, and the quality of evidence was appraised by the Newcastle-Ottawa Scale (NOS). This meta-analysis was prospectively registered online on PROSPERO, CRD42020191763. Results: Sixteen observational studies with 6386 COVID-19 patients relating hyperglycemia at admission to COVID-19 outcomes were included. The overall data demonstrated that, compared with the control, the hyperglycemia at admission group was more likely to have increased mortality (OR = 3.45, 95% CI, 2.26-5.26) and severe/critical complications (OR = 2.08, 95% CI, 1.45-2.99) of COVID-19. Conclusion: Hyperglycemia at admission in COVID-19 patients may be a strong predictor of mortality and complications.
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