Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 30, Issue 24, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2020.127559
Keywords
Cyclopropanes; Hydrazones; Anti-viral; HSV-1; Herpesvirus
Categories
Funding
- Stanley Foundation [13R-002, 07R-1712, R21 NS096405]
- NIH [R01 MH063480]
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The synthesis of a lead anti-viral cyclopropyl carboxy acyl hydrazone 4F17 (5) and three sequential arrays of structural analogues along with the initial assessment and optimization of the antiviral pharmacophore against the herpes simplex virus type 1 (HSV-1) are reported.
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