Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 36, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2021.127824
Keywords
Fluorene; Fluorenone; G-Quadruplex; c-myc; Light-up probe
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Funding
- Scientific and Technological Research Council of Turkey (TUBITAK) [113Z704]
- Scientific Research Projects Coordination Unit of Gazi University [05/2018-01]
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The research has identified fluorene/fluorenone derivatives with structure-specific binding towards dsRNA, showing potential for structure-selective ligands. Novel fluorene/fluorenone derivatives have been synthesized with selectivity towards various DNA structures, particularly G-quadruplexes, two of which exhibited strong affinity to the proto-oncogene c-myc promoter G-quadruplex.
The development of fluorescent dyes capable of selective recognition of G-quadruplexes is essential for studying its localization and biological functions. However, considering the G-quadruplex topologies may vary significantly, the synthesis of compounds showing both selectivity and strong fluorescence properties still remains a great challenge. Recently we have developed fluorene/fluorenone derivatives with structure-specific binding towards dsRNA, indicating its potential for structure-selective ligands. Herein, we report the synthesis of novel fluorene/fluorenone derivatives and their selectivity towards various DNA structures, particularly G-quadruplexes, two of which showed strong affinity to the proto-oncogene c-myc promoter G-quadruplex.
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