Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 29, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2020.115895
Keywords
Aurones; Synthesis; Biological activities
Funding
- National Natural Science Foundation of China [21901211]
- Natural Science Foundation of Shaanxi Province of China [2019JQ-640, 2019JQ-355]
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Aurones are naturally occurring structural isomerides of flavones with diverse bioactivities. This review provides an update on the synthesis and biological activities of Aurones, as well as proposing their potential as medicinal drugs based on structure-activity relationships.
Aurones are naturally occurring structural isomerides of flavones that have diverse bioactivities including antiviral, antibacterial, antifungal, anti-inflammatory, antitumor, antimalarial, antioxidant, neuropharmacological activities and so on. They constitute an important class of pharmacologically active scaffolds that exhibit multiple biological activities via diverse mechanisms. This review article provides an update on the recent advances (2013-2020.4) in the synthesis and biological activities of these derivatives. In the cases where sufficient information is available, some important structure-activity relationships (SAR) of their biological activities were presented, and on the strength of our expertise in medicinal chemistry and careful analysis of the recent literature, for the potential of aurones as medicinal drugs is proposed.
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