Related references
Note: Only part of the references are listed.The signal peptide as a new target for drug design
Liezel A. Lumangtad et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2020)
Iron-catalyzed regioselective cyclotrimerization of alkynes to benzenes
Suhas Shahaji Gawali et al.
JOURNAL OF ORGANOMETALLIC CHEMISTRY (2019)
Functionally Versatile and Highly Stable Chelator for 111In and 177Lu: Proof-of-Principle Prostate-Specific Membrane Antigen Targeting
Lily Li et al.
BIOCONJUGATE CHEMISTRY (2019)
GSK3732394: a Multi-specific Inhibitor of HIV Entry
David Wensel et al.
JOURNAL OF VIROLOGY (2019)
Tsuji-Trost Cyclization of Disulfonamides: Synthesis of 12-Membered, 11-Membered, and Pyridine-Fused Macrocyclic Triamines
Rameez Ali et al.
ACS OMEGA (2019)
Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases
Claudia Goettsch et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)
Medicinal chemistry of acridine and its analogues
Parteek Prasher et al.
MEDCHEMCOMM (2018)
A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA)
Victor Van Puyenbroeck et al.
MOLECULAR & CELLULAR PROTEOMICS (2017)
Improved synthesis of symmetrically & asymmetrically N-substituted pyridinophane derivatives
Andrew J. Wessel et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2017)
Highly Stereoselective Synthesis of Imidazolidines through the Palladium(0)-Catalyzed Three-Component Reaction of 2,3-Allenylamines, Organic Halides, and Imines
Jinxing Hu et al.
CHEMCATCHEM (2017)
Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41
Lu Lu et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)
Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends
Peng Zhan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Structure of the Sec61 channel opened by a signal sequence
Rebecca M. Voorhees et al.
SCIENCE (2016)
Model-Based Phase 3 Dose Selection for HIV-1 Attachment Inhibitor Prodrug BMS-663068 in HIV-1-Infected Patients: Population Pharmacokinetics/Pharmacodynamics of the Active Moiety, BMS-626529
Ishani Landry et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)
Sortilin: A novel regulator in lipid metabolism and atherogenesis
Li-yuan Zhong et al.
CLINICA CHIMICA ACTA (2016)
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles
Claudia Goettsch et al.
JOURNAL OF CLINICAL INVESTIGATION (2016)
Tuning Side Arm Electronics in Unsymmetrical Cyclotriazadisulfonamide (CADA) Endoplasmic Reticulum (ER) Translocation Inhibitors to Improve their Human Cluster of Differentiation 4 (CD4) Receptor Down-Modulating Potencies
Reena Chawla et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism
Arti B. Patel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Tregalizumab - A Monoclonal Antibody to Target Regulatory T Cells
Martin Koenig et al.
FRONTIERS IN IMMUNOLOGY (2016)
Pharmacokinetic Interactions between BMS-626529, the Active Moiety of the HIV-1 Attachment Inhibitor Prodrug BMS-663068, and Ritonavir or Ritonavir-Boosted Atazanavir in Healthy Subjects
Li Zhu et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Mechanisms of Integral Membrane Protein Insertion and Folding
Florian Cymer et al.
JOURNAL OF MOLECULAR BIOLOGY (2015)
Enzyme-Artificial Enzyme Interactions as a Means for Discriminating among Structurally Similar Isozymes
Karuthapandi Selvakumar et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
A new oxidation system for the oxidation of Hantzsch-1,4-dihydropyridines and polyhydroquinoline derivatives under mild conditions
Cui-Bing Bai et al.
RSC ADVANCES (2015)
Structures of the scanning and engaged states of the mammalian SRP-ribosome complex
Rebecca M. Voorhees et al.
ELIFE (2015)
A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway
Bianca Helling et al.
IMMUNOLOGY AND CELL BIOLOGY (2015)
Gated Electron Sharing Within Dynamic Naphthalene Diimide-Based Oligorotaxanes**
Alyssa-Jennifer Avestro et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
2-Aminothiazolones as Anti-HIV Agents That Act as gp120-CD4 Inhibitors
Marika Tiberi et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Recombinant IL-21 and anti-CD4 antibodies cooperate in syngeneic neuroblastoma immunotherapy and mediate long-lasting immunity
Valentina Rigo et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2014)
Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency
Wing C. Lee et al.
HUMAN MOLECULAR GENETICS (2014)
Rational Design and Characterization of the Novel, Broad and Potent Bispecific HIV-1 Neutralizing Antibody iMabm36
Ming Sun et al.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2014)
Antiretroviral Treatment of Adult HIV Infection 2014 Recommendations of the International Antiviral Society-USA Panel
Huldrych F. Guenthard et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)
Rings in Drugs
Richard D. Taylor et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Signal Peptide-Binding Drug as a Selective Inhibitor of Co-Translational Protein Translocation
Kurt Vermeire et al.
PLOS BIOLOGY (2014)
Alkyl Transfer from C-C Cleavage
Guangxun Li et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Activity of the HIV-1 Attachment Inhibitor BMS-626529, the Active Component of the Prodrug BMS-663068, against CD4-Independent Viruses and HIV-1 Envelopes Resistant to Other Entry Inhibitors
Zhufang Li et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
Molecular basis of human immunodeficiency virus type 1 drug resistance: Overview and recent developments
Luis Menendez-Arias
ANTIVIRAL RESEARCH (2013)
Entry inhibitors and their use in the treatment of HIV-1 infection
Aiman A. Haqqani et al.
ANTIVIRAL RESEARCH (2013)
Co-translational targeting and translocation of proteins to the endoplasmic reticulum
Yvonne Nyathi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)
HIV-1 entry inhibitors: recent development and clinical use
Timothy J. Henrich et al.
CURRENT OPINION IN VIROLOGY (2013)
Mechanisms of Sec61/SecY-Mediated Protein Translocation Across Membranes
Eunyong Park et al.
ANNUAL REVIEW OF BIOPHYSICS, VOL 41 (2012)
Improving potencies and properties of CD4 down-modulating CADA analogs
Thomas W. Bell et al.
EXPERT OPINION ON DRUG DISCOVERY (2012)
Mitigating Heterocycle Metabolism in Drug Discovery
David J. St Jean et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Rhenium-Catalyzed Regioselective Synthesis of Multisubstituted Pyridines from β-Enamino Ketones and Alkynes via C-C Bond Cleavage
Shun-ichi Yamamoto et al.
ORGANIC LETTERS (2012)
Alemtuzumab-resistant Sezary syndrome responding to zanolimumab
Anton B. Alexandroff et al.
BRITISH JOURNAL OF HAEMATOLOGY (2011)
Mammalian plasma membrane proteins as potential biomarkers and drug targets
Marijana Rucevic et al.
ELECTROPHORESIS (2011)
Symmetric Double-Headed Aminopyridines, a Novel Strategy for Potent and Membrane-Permeable Inhibitors of Neuronal Nitric Oxide Synthase
Fengtian Xue et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Unsymmetrical Cyclotriazadisulfonamide (CADA) Compounds as Human CD4 Receptor Down-Modulating Agents
Violeta G. Demillo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Tail-anchored membrane protein insertion into the endoplasmic reticulum
Ramanujan S. Hegde et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
Copper-Catalyzed Coupling of Oxime Acetates with Aldehydes: A New Strategy for Synthesis of Pyridines
Zhi-Hui Ren et al.
ORGANIC LETTERS (2011)
MTRX1011A, a humanized anti-CD4 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a Phase I randomized, double-blind, placebo-controlled study incorporating pharmacodynamic biomarker assessments
Heleen Scheerens et al.
ARTHRITIS RESEARCH & THERAPY (2011)
Synthesis of new enantiopure dimethyl- and diisobutyl -substituted pyridino-18-crown-6 ethers containing a halogen atom or a methoxy group at position 4 of the pyridine ring for enantiomeric recognition studies
Jozsef Kupai et al.
ARKIVOC (2011)
Entry inhibitors in the treatment of HIV-1 infection
John C. Tilton et al.
ANTIVIRAL RESEARCH (2010)
Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery
David C. Pryde et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin
Fenghua Hu et al.
NEURON (2010)
Optically active macrocyclic hexaazapyridinophanes decorated at the periphery: synthesis and applications in the NMR enantiodiscrimination of carboxylic acids
Eduardo Busto et al.
TETRAHEDRON (2010)
Oxidative aromatization of 1,4-dihydropyridines and pyrazolines using HbA-H2O2: An efficient biomimetic catalyst system providing metabolites of drug candidates
Atul Kumar et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Human Immunodeficiency Virus Type 1 Escape from Cyclotriazadisulfonamide-Induced CD4-Targeted Entry Inhibition Is Associated with Increased Neutralizing Antibody Susceptibility
Kurt Vermeire et al.
JOURNAL OF VIROLOGY (2009)
CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection
Coreen M. Beaumier et al.
NATURE MEDICINE (2009)
HIV Entry Inhibitors and Their Potential in HIV Therapy
Keduo Qian et al.
MEDICINAL RESEARCH REVIEWS (2009)
Pyridine-based lanthanide complexes: towards bimodal agents operating as near infrared luminescent and MRI reporters
Laurent Pellegatti et al.
CHEMICAL COMMUNICATIONS (2008)
In Vitro Solubility Assays in Drug Discovery
Edward H. Kerns et al.
CURRENT DRUG METABOLISM (2008)
An efficient, metal-free, room temperature aromatization of Hantzsch-1,4-dihydropyridines with urea-hydrogen peroxide adduct, catalyzed by molecular iodine
Mirela Filipan-Litvic et al.
TETRAHEDRON (2008)
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes
Tom A. Rapoport
NATURE (2007)
Clinical efficacy of zanolimumab (HuMax-CD4):: two phase 2 studies in refractory cutaneous T-cell lymphoma
Youn H. Kim et al.
BLOOD (2007)
The synthesis and property of dihydropyrene derivatives containing a nitrogen atom
Kazufumi Chifuku et al.
MOLECULAR CRYSTALS AND LIQUID CRYSTALS (2007)
Synthesis and structure-activity relationship studies of CD4 down-modulating cyclotriazadisulfonamide (CADA) analogues
TW Bell et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Inhibitors of HIV infection via the cellular CD4 receptor
K Vermeire et al.
CURRENT MEDICINAL CHEMISTRY (2006)
Free-radical approach to 4-substituted dipicolinates
R Shelkov et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2005)
CD4 down-modulating compounds with potent anti-HIV activity
K Vermeire et al.
CURRENT PHARMACEUTICAL DESIGN (2004)
Synthesis of dicyanopyridines
E Roblou et al.
SYNTHETIC COMMUNICATIONS (2004)
Reactivity of the acridine ring: One-pot regioselective single and double bromomethylation of acridine and some derivatives
J Chiron et al.
SYNLETT (2003)
A generic approach for the catalytic reduction of nitriles
S Caddick et al.
TETRAHEDRON (2003)
Synthesis of 4-functionalized terdendate pyridine-based ligands
T Vermonden et al.
TETRAHEDRON (2003)
Specific CD4 down-modulating compounds with potent anti-HIV activity
K Vermeire et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2003)
The anti-HIV potency of cyclotriazadisulfonamide analogs is directly correlated with their ability to down-modulate the CD4 receptor
K Vermeire et al.
MOLECULAR PHARMACOLOGY (2003)
Synthesis and coordination chemistry of arene soluble 4-alkyl-2,6-bis[(diphenylphosphino)methyl]pyridine N,P,P '-trioxide ligands
XM Gan et al.
DALTON TRANSACTIONS (2003)
Role of pyridine hydrogen-bonding sites in recognition of basic amino acid side chains
TW Bell et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
Research on heterocyclic compounds. XLIII. Synthetic studies on 1,4-dihydropyridine derivatives
MG Rimoli et al.
JOURNAL OF HETEROCYCLIC CHEMISTRY (2002)
CADA inhibits human immunodeficiency virus and human herpesvirus 7 replication by down-modulation of the cellular CD4 receptor
K Vermeire et al.
VIROLOGY (2002)
Structure-activity relationships in platelet-activating factor (PAF).: 11-From PAF-antagonism to phospholipase A2 inhibition:: syntheses and structure-activity relationships in 1-arylsulfamido-2-alkylpiperazines
C Binisti et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2001)
Pharmacokinetic, pharmacodynamic and clinical effects of a humanized IgG1 anti-CD4 monoclonal antibody in the peripheral blood and synovial fluid of rheumatoid arthritis patients
EHS Choy et al.
RHEUMATOLOGY (2000)
A high-throughput screening method for the determination of aqueous drug solubility using laser nephelometry in microtiter plates
CD Bevan et al.
ANALYTICAL CHEMISTRY (2000)
Share Paper
