Related references
Note: Only part of the references are listed.MK-2206 and Standard Neoadjuvant Chemotherapy Improves Response in Patients With Human Epidermal Growth Factor Receptor 2-Positive and/or Hormone Receptor-Negative Breast Cancers in the I-SPY 2 Trial
A. Jo Chien et al.
JOURNAL OF CLINICAL ONCOLOGY (2020)
The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism
Gerta Hoxhaj et al.
NATURE REVIEWS CANCER (2020)
Protocol Update for large-scale genome and gene function analysis with the PANTHER classification system (v.14.0)
Huaiyu Mi et al.
NATURE PROTOCOLS (2019)
Dynamics and distribution of paxillin, vinculin, zyxin and VASP depend on focal adhesion location and orientation
Karin Legerstee et al.
SCIENTIFIC REPORTS (2019)
Pivotal Role of AKT2 during Dynamic Phenotypic Change of Breast Cancer Stem Cells
Petra Gener et al.
CANCERS (2019)
Tumor-treating fields induce autophagy by blocking the Akt2/miR29b axis in glioblastoma cells
Eun Ho Kim et al.
ONCOGENE (2019)
Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids
Eamonn J. Dickson et al.
BIOCHEMICAL JOURNAL (2019)
Cell Cycle and Beyond: Exploiting New RB1 Controlled Mechanisms for Cancer Therapy
Erik S. Knudsen et al.
TRENDS IN CANCER (2019)
Nanobodies targeting cortactin proline rich, helical and actin binding regions downregulate invadopodium formation and matrix degradation in SCC-61 cancer cells
Laurence Bertier et al.
BIOMEDICINE & PHARMACOTHERAPY (2018)
AKT isoform-specific expression and activation across cancer lineages
Jue Wang et al.
BMC CANCER (2018)
The complex relationship between TFEB transcription factor phosphorylation and subcellular localization
Rosa Puertollano et al.
EMBO JOURNAL (2018)
QCloud: A cloud-based quality control system for mass spectrometry-based proteomics laboratories
Cristina Chiva et al.
PLOS ONE (2018)
Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation
Jiuli Zhou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Cortactin and fascin-1 regulate extracellular vesicle release by controlling endosomal trafficking or invadopodia formation and function
Els Beghein et al.
SCIENTIFIC REPORTS (2018)
Inhibitory cortactin nanobodies delineate the role of NTA- and SH3-domain-specific functions during invadopodium formation and cancer cell invasion
Laurence Bertier et al.
FASEB JOURNAL (2017)
PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
Michael Ebner et al.
MOLECULAR CELL (2017)
Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis
E. Agarwal et al.
ONCOGENE (2017)
Maximising the potential of MKT inhibitors as anti-cancer treatments
Jessica S. Brown et al.
PHARMACOLOGY & THERAPEUTICS (2017)
VCA nanobodies target N- WASp to reduce invadopodium formation and functioning
Tim Hebbrecht et al.
PLOS ONE (2017)
AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins
Marina Riggio et al.
SCIENTIFIC REPORTS (2017)
AKT/PKB Signaling: Navigating the Network
Brendan D. Manning et al.
CELL (2017)
Recurrent AKT mutations in human cancers: functional consequences and effects on drug sensitivity
Kyung H. Yi et al.
ONCOTARGET (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky et al.
AUTOPHAGY (2016)
The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation
Tsung-Chieh Lin et al.
ELIFE (2016)
Nanobodies as Versatile Tools to Understand, Diagnose, Visualize and Treat Cancer
Isabel Van Audenhove et al.
EBIOMEDICINE (2016)
A new survivin tracer tracks, delocalizes and captures endogenous survivin at different subcellular locations and in distinct organelles
Els Beghein et al.
SCIENTIFIC REPORTS (2016)
Signalling specificity in the Akt pathway in breast cancer
Abbe R. Clark et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2014)
Mirk/dyrk1B kinase is upregulated following inhibition of mTOR
Xiaobing Deng et al.
CARCINOGENESIS (2014)
Phase 1 trial of the oral AKT inhibitor MK-2206 plus carboplatin/paclitaxel, docetaxel, or erlotinib in patients with advanced solid tumors
L. Rhoda Molife et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2014)
Picking the Point of Inhibition: A Comparative Review of PI3K/AKT/mTOR Pathway Inhibitors
Rodrigo Dienstmann et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Discovery and saturation analysis of cancer genes across 21 tumour types
Michael S. Lawrence et al.
NATURE (2014)
Step-by-step quantitative analysis of focal adhesions
Utku Horzum et al.
METHODSX (2014)
Distinct and specific roles of AKT1 and AKT2 in androgen-sensitive and androgen-independent prostate cancer cells
Ariel E. Cariaga-Martinez et al.
CELLULAR SIGNALLING (2013)
A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis
Katrien Van Impe et al.
BREAST CANCER RESEARCH (2013)
A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle
Yu-Chiang Lai et al.
BIOCHEMICAL JOURNAL (2012)
Biomarkers of Response to Akt Inhibitor MK-2206 in Breast Cancer
Takafumi Sangai et al.
CLINICAL CANCER RESEARCH (2012)
Actopaxin (α-Parvin) Phosphorylation Is Required for Matrix Degradation and Cancer Cell Invasion
Jeanine Pignatelli et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Antibody-enabled small-molecule drug discovery
Alastair D. G. Lawson
NATURE REVIEWS DRUG DISCOVERY (2012)
A practical guide to evaluating colocalization in biological microscopy
Kenneth W. Dunn et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2011)
Roles of AKT1 and AKT2 in non-small cell lung cancer cell survival, growth, and migration
Myoung W. Lee et al.
CANCER SCIENCE (2011)
Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis
E. K. Kim et al.
ONCOGENE (2011)
Ablation of Akt2 Induces Autophagy through Cell Cycle Arrest, the Downregulation of p70S6K, and the Deregulation of Mitochondria in MDA-MB231 Cells
Stacey A. Santi et al.
PLOS ONE (2011)
TFEB Links Autophagy to Lysosomal Biogenesis
Carmine Settembre et al.
SCIENCE (2011)
Akt isoform-specific signaling in breast cancer Uncovering an anti-migratory role of palladin
Y. Rebecca Chin et al.
CELL ADHESION & MIGRATION (2011)
The Akt isoforms are present at distinct subcellular locations
Stacey A. Santi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2010)
Akt2-mediated phosphorylation of Pitx2 controls Ccnd1 mRNA decay during muscle cell differentiation
R. Gherzi et al.
CELL DEATH AND DIFFERENTIATION (2010)
A llama-derived gelsolin single-domain antibody blocks gelsolin-G-actin interaction
Anske Van den Abbeele et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2010)
Akt2 regulates expression of the actin-bundling protein palladin
Y. Rebecca Chin et al.
FEBS LETTERS (2010)
A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic α-Exosite Binding Region
Jianbo Dong et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
The Actin-Bundling Protein Palladin Is an Akt1-Specific Substrate that Regulates Breast Cancer Cell Migration
Y. Rebecca Chin et al.
MOLECULAR CELL (2010)
The nuts and bolts of AGC protein kinases
Laura R. Pearce et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Akt1 and Akt2 Play Distinct Roles in the Initiation and Metastatic Phases of Mammary Tumor Progression
Rachelle L. Dillon et al.
CANCER RESEARCH (2009)
p27Kip1 Inhibits Cyclin D-Cyclin-Dependent Kinase 4 by Two Independent Modes (Publication with Expression of Concern. See vol. 42, 2022)
Arpita Ray et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Reduction of Akt2 expression inhibits chemotaxis signal transduction in human breast cancer cells
Jingna Wang et al.
CELLULAR SIGNALLING (2008)
Podosome-type adhesions and focal adhesions, so alike yet so different
Marc R. Block et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2008)
DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing
Ben Harrison et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The PTEN-PI3K pathway: of feedbacks and cross-talks
A. Carracedo et al.
ONCOGENE (2008)
Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains
Debasis Manna et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines
Sandra Koseoglu et al.
CANCER BIOLOGY & THERAPY (2007)
The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention
John P. Alao
MOLECULAR CANCER (2007)
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
John Brognard et al.
MOLECULAR CELL (2007)
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/Neu and MMTV-polyoma middle T transgenic mice
Ioanna G. Maroulakou et al.
CANCER RESEARCH (2007)
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα but not S6K1
David A. Guertin et al.
DEVELOPMENTAL CELL (2006)
Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding
Lisa Heron-Milhavet et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
Estela Jacinto et al.
CELL (2006)
Induction of autophagy in axonal dystrophy and degeneration
Qing Jun Wang et al.
JOURNAL OF NEUROSCIENCE (2006)
Kinetic mechanism of AKT/PKB enzyme family
Xiaoling Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Essential roles of PI-3K/Akt/IKKβ/NFκB pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells
W Ouyang et al.
CARCINOGENESIS (2006)
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
HY Irie et al.
JOURNAL OF CELL BIOLOGY (2005)
Regulation of the Akt kinase by interacting proteins
KY Du et al.
ONCOGENE (2005)
Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67
IJL Byeon et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Role for Akt3/Protein kinase Bγ in attainment of normal brain size
RM Easton et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence
N Blom et al.
PROTEOMICS (2004)
Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression
Jiyong Liang et al.
CELL CYCLE (2003)
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP
J Yang et al.
NATURE STRUCTURAL BIOLOGY (2002)
Novel targets of Akt, p21CipI/WAFI, and MDM2
BHP Zhou et al.
SEMINARS IN ONCOLOGY (2002)
Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene
WS Chen et al.
GENES & DEVELOPMENT (2001)
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
H Cho et al.
SCIENCE (2001)
Share Paper
