cGAS-STING signaling in cancer immunity and immunotherapy

Recent studies have shown that the innate immune cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway may play an important role in antitumor immunity. Additionally, the cGAS-STING pathway promotes the senescence of cancer cells, induces apoptosis of cancer cells, and increases the protective effect of cytotoxic T cells and natural killer cell-mediated cytotoxicity. We believe that the combination of the cGAS-STING signaling pathway with other therapeutic methods provides a new perspective from which to overcome obstacles in the application of this review. Further, we highlight the antitumor mechanism of the cGAS-STING signaling pathway and the latest advances in monotherapy and combination therapy with related agonists.

Automated summary

Recent studies have revealed that the cGAS-STING pathway plays a crucial role in antitumor immunity, promoting senescence and apoptosis of cancer cells while enhancing the protective effects of cytotoxic T cells and natural killer cells. Combining the cGAS-STING signaling pathway with other therapeutic methods offers a new perspective for overcoming obstacles in its application.