Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 133, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2020.110968
Keywords
Traditional Chinese medicine; Autophagy; Neurodegenerative disease; Neuroprotection
Funding
- National Natural Science Foundation of China [NSFC-81703487, NSFC-81773926]
- Hong Kong Government [HKBU12101417, HKBU12100618, HMRF17182541, HMRF17182551]
- Shenzhen Science and Technology Innovation Commission [JCYJ 20180302174028790, JCYJ20180507184656626]
- Hong Kong Baptist University [RC-IRCs/17-18/03, RCIRCMS/19-20/H02]
Ask authors/readers for more resources
Neurodegenerative diseases (NDs) are common chronic diseases related to progressive damage of the nervous system, with autophagy playing a key role in the neurodegeneration process. Traditional Chinese medicine (TCM) regulating autophagy shows potential as a therapy for NDs.
Neurodegenerative diseases (NDs) are common chronic diseases related to progressive damage of the nervous system. Globally, the number of people with an ND is dramatically increasing consistent with the fast aging of society and one of the common features of NDs is the abnormal aggregation of diverse proteins. Autophagy is the main process by which misfolded proteins and damaged organelles are removed from cells. It has been found that the impairment of autophagy is associated with many NDs, suggesting that autophagy has a vital role in the neurodegeneration process. Recently, more and more studies have reported that autophagy inducers display a protective role in different ND experimental models, suggesting that enhancement of autophagy could be a potential therapy for NDs. In this review, the evidence for beneficial effects of traditional Chinese medicine (TCM) regulate autophagy in the models of Alzheimer's disease (AD), Parkinson's disease (PD), and other NDs are presented and common autophagy-related mechanisms are identified. The results demonstrate that TCM which regulate autophagy are potential therapeutic candidates for ND treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available