4.7 Review

Development of small molecule inhibitors/agonists targeting STING for disease

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonists

Shi Hou et al.

BIOORGANIC CHEMISTRY (2020)

Article Immunology

Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP

Vladislav Pokatayev et al.

NATURE IMMUNOLOGY (2020)

Review Oncology

The Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer

John Kwon et al.

CANCER DISCOVERY (2020)

Article Immunology

A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome

Zimu Deng et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Article Immunology

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

Alice Lepelley et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Review Oncology

cGAS-STING, an important pathway in cancer immunotherapy

Minlin Jiang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Article Multidisciplinary Sciences

C9orf72 in myeloid cells suppresses STING-induced inflammation

Madelyn E. McCauley et al.

NATURE (2020)

Article Multidisciplinary Sciences

An orally available non-nucleotide STING agonist with antitumor activity

Bo-Sheng Pan et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic

Emily N. Chin et al.

SCIENCE (2020)

Article Biochemistry & Molecular Biology

Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

Jiang Dai et al.

Review Medicine, General & Internal

Association of Aspirin Use for Primary Prevention With Cardiovascular Events and Bleeding Events A Systematic Review and Meta-analysis

Sean L. Zheng et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

Article Multidisciplinary Sciences

Structural basis of STING binding with and phosphorylation by TBK1

Conggang Zhang et al.

NATURE (2019)

Article Multidisciplinary Sciences

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP

Guijun Shang et al.

NATURE (2019)

Review Biochemistry & Molecular Biology

Function of Green Tea Catechins in the Brain: Epigallocatechin Gallate and its Metabolites

Monira Pervin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Cell Biology

Innate immunity signalling and membrane trafficking

Tomohiko Taguchi et al.

CURRENT OPINION IN CELL BIOLOGY (2019)

Article Immunology

G3BP1 promotes DNA binding and activation of cGAS

Zhao-Shan Liu et al.

NATURE IMMUNOLOGY (2019)

Article Chemistry, Medicinal

Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING

Tony Siu et al.

ACS MEDICINAL CHEMISTRY LETTERS (2019)

Article Chemistry, Medicinal

Design and synthesis of plant cyclopeptide Astin C analogues and investigation of their immunosuppressive activity

Fei Li et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

Article Multidisciplinary Sciences

Chromosomal instability drives metastasis through a cytosolic DNA response

Samuel F. Bakhoum et al.

NATURE (2018)

News Item Biotechnology & Applied Microbiology

Can innate immune system targets turn up the heat on 'cold' tumours?

Asher Mullard

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Multidisciplinary Sciences

Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease

Qiang Ding et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Chemistry, Medicinal

Identification of -Mangostin as an Agonist of Human STING

Yibo Zhang et al.

CHEMMEDCHEM (2018)

Review Chemistry, Medicinal

Recent advances in small molecule based cancer immunotherapy

Binbin Cheng et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Parkin and PINK1 mitigate STING-induced inflammation

Danielle A. Sliter et al.

NATURE (2018)

Article Multidisciplinary Sciences

Targeting STING with covalent small-molecule inhibitors

Simone M. Haag et al.

NATURE (2018)

Article Multidisciplinary Sciences

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

Anne Louise Hansen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Design of amidobenzimidazole STING receptor agonists with systemic activity

Joshi M. Ramanjulu et al.

NATURE (2018)

Article Rheumatology

Familial chilblain lupus due to a gain-of-function mutation in STING

Nadja Konig et al.

ANNALS OF THE RHEUMATIC DISEASES (2017)

Review Food Science & Technology

Medicinal properties of mangosteen (Garcinia mangostana L.): A comprehensive update

Berenice Ovalle-Magallanes et al.

FOOD AND CHEMICAL TOXICOLOGY (2017)

Review Biochemistry & Molecular Biology

cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response

Debojit Bose

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Chemistry, Physical

Single Mutations Reshape the Structural Correlation Network of the DMXAA-Human STING Complex

Xing Che et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2017)

Article Multidisciplinary Sciences

Mitotic progression following DNA damage enables pattern recognition within micronuclei

Shane M. Harding et al.

NATURE (2017)

Review Biochemistry & Molecular Biology

Versatile modes of cellular regulation via cyclic dinucleotides

Petya Violinova Krasteva et al.

NATURE CHEMICAL BIOLOGY (2017)

Review Oncology

Role of Aspirin in Breast Cancer Survival

Wendy Y. Chen et al.

CURRENT ONCOLOGY REPORTS (2017)

Article Multidisciplinary Sciences

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Jessica Vincent et al.

NATURE COMMUNICATIONS (2017)

Article Pharmacology & Pharmacy

A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists

Bowei Liu et al.

ANTIVIRAL RESEARCH (2017)

Review Medicine, Research & Experimental

The host STING pathway at the interface of cancer and immunity

Leticia Corrales et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Virology

cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection

Chan-Wang J. Lio et al.

JOURNAL OF VIROLOGY (2016)

Article Multidisciplinary Sciences

Activation of STING requires palmitoylation at the Golgi

Kojiro Mukai et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMPSTING-IRF3 Mediated Innate Immune Response

Tiejun Li et al.

SCIENTIFIC REPORTS (2016)

Article Microbiology

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

Angela C. Collins et al.

CELL HOST & MICROBE (2015)

Article Chemistry, Multidisciplinary

Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma

Takashi Nakamura et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Article Multidisciplinary Sciences

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

Daxing Gao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Immunology

STING: infection, inflammation and cancer

Glen N. Barber

NATURE REVIEWS IMMUNOLOGY (2015)

Review Biochemistry & Molecular Biology

Role of DNA/RNA sensors and contribution to autoimmunity

Siobhan Smith et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2014)

Article Medicine, Research & Experimental

Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

Nadia Jeremiah et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Virology

Adenovirus Detection by the cGAS/STING/TBK1 DNA Sensing Cascade

Eric Lam et al.

JOURNAL OF VIROLOGY (2014)

Review Biochemistry & Molecular Biology

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

Xin Cai et al.

MOLECULAR CELL (2014)

Article Biochemistry & Molecular Biology

Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

Lingyin Li et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Medicine, General & Internal

Activated STING in a Vascular and Pulmonary Syndrome

Y. Liu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Multidisciplinary Sciences

Inflammation-driven carcinogenesis is mediated through STING

Jeonghyun Ahn et al.

NATURE COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

Anticancer Flavonoids Are Mouse-Selective STING Agonists

Sujeong Kim et al.

ACS CHEMICAL BIOLOGY (2013)

Article Multidisciplinary Sciences

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

Andrea Ablasser et al.

NATURE (2013)

Review Microbiology

Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

Ute Romling et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2013)

Article Multidisciplinary Sciences

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

Xiao-Dong Li et al.

SCIENCE (2013)

Article Multidisciplinary Sciences

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

Daxing Gao et al.

SCIENCE (2013)

Article Multidisciplinary Sciences

STING manifests self DNA-dependent inflammatory disease

Jeonghyun Ahn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

STING is a direct innate immune sensor of cyclic di-GMP

Dara L. Burdette et al.

NATURE (2011)

Review Biochemistry & Molecular Biology

Pattern Recognition Receptors and Inflammation

Osamu Takeuchi et al.

Article Immunology

IFI16 is an innate immune sensor for intracellular DNA

Leonie Unterholzner et al.

NATURE IMMUNOLOGY (2010)

Article Multidisciplinary Sciences

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

Tatsuya Saitoh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Trex1 prevents cell-intrinsic initiation of autoimmunity

Daniel B. Stetson et al.

Article Multidisciplinary Sciences

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

Akinori Takaoka et al.

NATURE (2007)

Article Hematology

The mechanism of action of aspirin

JR Vane et al.

THROMBOSIS RESEARCH (2003)

Article Cell Biology

The RasGAP-associated endoribonuclease G3BP assembles stress granules

H Tourrière et al.

JOURNAL OF CELL BIOLOGY (2003)