Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 132, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2020.110945
Keywords
Stimulator of interferon genes; Disease; Innate immune response; Small molecule inhibitors; Small molecule agonists
Funding
- Guangdong Medical University [B2019016]
- Administration of Traditional Chinese Medicine of Guangdong Province [20201180]
- Science and Technology Special Project of Zhanjiang [2019A01009]
- Natural Science Foundation of Guangdong Province [2016B030309002]
- Basic and Applied Basic Research Program of Guangdong Province [2019A1515110201]
- Educational Commission of Guangdong Province [4SG20138G]
- Fund of Southern Marine Science and Engineering GuangdongLaboratory (Zhanjiang) [ZJW-2019-007]
- GDNRC [[2020]038]
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Cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is the primary immune response pathway in the cytoplasm. Pharmacological regulation of the STING pathway has good characteristics in both structure and function, which plays a significant role in the immunotherapy of autoimmune diseases, autoinflammatory diseases, and cancer. In this review, we summarized the activation of STING signaling pathway, the STING-related diseases, the development principle and the latest progress of inhibitors and agonists targeting STING. Our review demonstrates that STING signal pathway is a promising drug target, providing effective clues and correct guidance for the discovery of novel small molecule inhibitors/agonists that targeted STING for cancer, autoimmune, and inflammatory diseases.
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