4.7 Review

WNT/β-catenin signaling in the development of liver cancers

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis

Youn-Sang Jung et al.

Summary: The study reveals that TMEM9 hyperactivates Wnt signaling for liver regeneration and tumorigenesis through lysosomal degradation of APC. TMEM9 is highly expressed in regenerating liver and hepatocellular carcinoma (HCC) cells. In HCC, TMEM9 is overexpressed and necessary to maintain beta-catenin hyperactivation.

HEPATOLOGY (2021)

Review Oncology

Molecular Pathogenesis of Cholangiocarcinoma

Peter L. Labib et al.

BMC CANCER (2019)

Review Cell Biology

Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates

Kristina N. Schaefer et al.

DEVELOPMENTAL CELL (2019)

Article Biochemistry & Molecular Biology

Genome-Wide Identification and Expression Profiling of Wnt Family Genes in the Silkworm, Bombyx mori

Xin Ding et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis

Rongkun Li et al.

MOLECULAR CANCER (2019)

Article Cell Biology

EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells

Stephanie Grainger et al.

NATURE CELL BIOLOGY (2019)

Article Surgery

Cholangiocarcinoma

Adeel S. Khan et al.

SURGICAL CLINICS OF NORTH AMERICA (2019)

Review Gastroenterology & Hepatology

Molecular and histological correlations in liver cancer

Julien Calderaro et al.

JOURNAL OF HEPATOLOGY (2019)

Review Medicine, Research & Experimental

Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy

Dan Liu et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Cell Biology

WNT Signaling in Disease

Li Fang Ng et al.

CELLS (2019)

Article Biochemistry & Molecular Biology

Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

Qiang Gao et al.

Article Biotechnology & Applied Microbiology

Translation of the circular RNA circ-catenin promotes liver cancer cell growth through activation of the Wnt pathway

Wei-Cheng Liang et al.

GENOME BIOLOGY (2019)

Review Oncology

Cholangiocarcinoma - evolving concepts and therapeutic strategies

Sumera Rizvi et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Cell Biology

Loss of E-Cadherin-Dependent Cell-Cell Adhesion and the Development and Progression of Cancer

Heather C. Bruner et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

Article Oncology

Cancer Statistics, 2018

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

Review Oncology

Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors

Nithya Krishnamurthy et al.

CANCER TREATMENT REVIEWS (2018)

Review Cell Biology

Multiprotein complexes governing Wnt signal transduction

Melissa Gammons et al.

CURRENT OPINION IN CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Long non-coding RNA CCAL promotes hepatocellular carcinoma progression by regulating AP-2 alpha and Wnt/beta-catenin pathway

Yu Liu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Article Multidisciplinary Sciences

Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid

Xian-Yang Qin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biotechnology & Applied Microbiology

A utophagy suppresses proliferation of HepG2 cells via inhibiting glypican-3/wnt/beta-catenin signaling

Pei Hu et al.

ONCOTARGETS AND THERAPY (2018)

Review Pathology

Wnt/beta-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology

Jacquelyn O. Russell et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 13 (2018)

Review Biochemistry & Molecular Biology

Role of hypoxia-induced exosomes in tumor biology

Chuchu Shao et al.

MOLECULAR CANCER (2018)

Article Multidisciplinary Sciences

Identification of RSPO2 Fusion Mutations and Target Therapy Using a Porcupine Inhibitor

Chong Li et al.

SCIENTIFIC REPORTS (2018)

Review Oncology

Role of Wnt/β-catenin signaling in hepatocellular carcinoma, pathogenesis, and clinical significance

Ahmed M. Khalaf et al.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2018)

Article Oncology

Wnt5b-associated exosomes promote cancer cell migration and proliferation

Takeshi Harada et al.

CANCER SCIENCE (2017)

Article Oncology

HCRP1 inhibits TGF-β induced epithelial-mesenchymal transition in hepatocellular carcinoma

Wenlin Yang et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2017)

Article Gastroenterology & Hepatology

Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification

Julien Calderaro et al.

JOURNAL OF HEPATOLOGY (2017)

Article Gastroenterology & Hepatology

SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma

Maite Merino-Azpitarte et al.

JOURNAL OF HEPATOLOGY (2017)

Article Biochemistry & Molecular Biology

A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation

Claudio Cantu et al.

SCIENCE SIGNALING (2017)

Article Biochemistry & Molecular Biology

A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation

Claudio Cantu et al.

SCIENCE SIGNALING (2017)

Article Medicine, Research & Experimental

Long noncoding RNA PCAT1 regulates extrahepatic cholangiocarcinoma progression via the Wnt/β-catenin-signaling pathway

Fumin Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Review Cell Biology

Complexity of the Wnt/β-catenin pathway: Searching for an activation model

Giovane G. Tortelote et al.

CELLULAR SIGNALLING (2017)

Article Biochemistry & Molecular Biology

Synergistic effects of CD44 and TGF-β1 through AKT/GSK-3β/β-catenin signaling during epithelial-mesenchymal transition in liver cancer cells

Na Ri Park et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Oncology

Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin

Shanthi Ganesh et al.

MOLECULAR CANCER THERAPEUTICS (2016)

Article Biochemistry & Molecular Biology

lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal

Pingping Zhu et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Review Gastroenterology & Hepatology

Aberrant regulation of Wnt signaling in hepatocellular carcinoma

Li-Juan Liu et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

Article Biochemistry & Molecular Biology

lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal

Pingping Zhu et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Review Gastroenterology & Hepatology

β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis

Satdarshan Pal Monga

GASTROENTEROLOGY (2015)

Article Medicine, Research & Experimental

WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited

Luke Boulter et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Gastroenterology & Hepatology

FAK Is Required for c-Met/beta-Catenin-Driven Hepatocarcinogenesis

Na Shang et al.

HEPATOLOGY (2015)

Article Biochemistry & Molecular Biology

PFTK1 interacts with cyclin Y to activate non-canonical Wnt signaling in hepatocellular carcinoma

Tingting Sun et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis

Taranjit S. Gujral et al.

Article Biotechnology & Applied Microbiology

Promoter Methylation of SFRP3 Is Frequent in Hepatocellular Carcinoma

Ya-Wen Lin et al.

DISEASE MARKERS (2014)

Editorial Material Pharmacology & Pharmacy

The potential of targeting Wnt/β-catenin in colon cancer

Ana Sebio et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2014)

Article Gastroenterology & Hepatology

Global Alterations of DNA Methylation in Cholangiocarcinoma Target the Wnt Signaling Pathway

Benjamin Goeppert et al.

HEPATOLOGY (2014)

Article Biochemistry & Molecular Biology

Toggling a conformational switch in Wnt/β-catenin signaling: Regulation of Axin phosphorylation

Ofelia Tacchelly-Benites et al.

BIOESSAYS (2013)

Review Gastroenterology & Hepatology

Wnt signaling and hepatocarcinogenesis: Molecular targets for the development of innovative anticancer drugs

Floriane Pez et al.

JOURNAL OF HEPATOLOGY (2013)

Article Cell Biology

Secreted and Transmembrane Wnt Inhibitors and Activators

Cristina-Maria Cruciat et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Review Biochemistry & Molecular Biology

Wnt/β-Catenin Signaling and Disease

Hans Clevers et al.

Review Biochemistry & Molecular Biology

The many faces and functions of β-catenin

Tomas Valenta et al.

EMBO JOURNAL (2012)

Article Biochemistry & Molecular Biology

Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis

Giray Bozkaya et al.

MOLECULAR CANCER (2012)

Article Multidisciplinary Sciences

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

Austin Gurney et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Gastroenterology & Hepatology

Pharmacological inhibition of Frizzled-7 displays anti-tumor properties in hepatocellular carcinoma

Sarah Beseme Nambotin et al.

JOURNAL OF HEPATOLOGY (2011)

Article Cell Biology

β-catenin signaling involves HGF-enhanced HepG2 scattering through activating MMP-7 transcription

Fei-Yan Pan et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2010)

Article Oncology

Noncanonical Wnt11 Inhibits Hepatocellular Carcinoma Cell Proliferation and Migration

Takashi Toyama et al.

MOLECULAR CANCER RESEARCH (2010)

Article Biochemistry & Molecular Biology

Wnt signal transduction pathways

Yuko Komiya et al.

Organogenesis (2010)

Article Biochemistry & Molecular Biology

Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells

Haluk Yuzugullu et al.

MOLECULAR CANCER (2009)

Review Biochemistry & Molecular Biology

Molecular components of the adherens junction

Carien M. Niessen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2008)

Review Gastroenterology & Hepatology

WNT/β-catenin signaling in liver health and disease

Michael D. Thompson et al.

HEPATOLOGY (2007)

Review Oncology

Hepatocellular carcinoma pathogenesis: from genes to environment

Paraskevi A. Farazi et al.

NATURE REVIEWS CANCER (2006)

Review Cell Biology

Wnt signaling in disease and in development

R Nusse

CELL RESEARCH (2005)