Journal
BIOMEDICAL MATERIALS
Volume 16, Issue 2, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1748-605X/abd051
Keywords
Nostoc commune Vaucher; microcapsules; wound healing
Funding
- National Natural Science Foundation of China [31460032]
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The study showed that UAP microcapsules significantly promote wound healing, potentially by enhancing immunity and increasing the expression of VEGF and miR-21 to promote angiogenesis and granulation growth.
Biologically active coating materials could promote the growth of granulation tissue as auxiliary materials, while natural polysaccharides could promote vascular regeneration and wound healing. Therefore, in this study, ultrasound-assisted extract of Nostoc commune Vaucher polysaccharides (UAP) yield after the process optimization was 12.89 +/- 0.24%, which was used to prepare microcapsules by emulsification and cross-linking. The effect of alginate/chitosan-UAP composite materials on wound healing in an experimental rat model for 14 d and its physical properties were evaluated. In vitro experiments indicated that the UAP microcapsule material had a porous and loose three-dimensional network structure, and had good biocompatibility and swelling properties as a wound healing material. Animal experiments indicated that UAP microcapsules could extremely significantly promote wound healing (P < 0.01), and wound closure rate reached 79.16 +/- 3.91% on 14th day. Meanwhile UAP microcapsules might promote angiogenesis and granulation growth by enhancing immunity and increasing the expression of VEGF and miR-21. Therefore, the composites of UAP microcapsules have shown encouraging results as a potential dressing for wound healing.
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