Regulation of RNA stability at the 3′ end

RNA homeostasis is regulated by a multitude of cellular pathways. Although the addition of untemplated adenine residues to the 3' end of mRNAs has long been known to affect RNA stability, newly developed techniques for 3'-end sequencing of RNAs have revealed various unexpected RNA modifications. Among these, uridylation is most recognized for its role in mRNA decay but is also a key regulator of numerous RNA species, including miRNAs and tRNAs, with dual roles in both stability and maturation of miRNAs. Additionally, low levels of untemplated guanidine and cytidine residues have been observed as parts of more complex tailing patterns.

Automated summary

RNA homeostasis is regulated by various cellular pathways, with different 3' end modifications affecting RNA stability and maturation. Uridylation plays a crucial role in mRNA decay and is also a key regulator of various RNA species such as miRNAs and tRNAs, with dual regulatory functions. Additionally, low levels of untemplated guanine and cytidine residues have been observed as part of more complex tailing patterns.