Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 44, Issue 1, Pages 136-139Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.b20-00584
Keywords
hexahydrocurcumin; microflora; optical activity; curcumin
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Funding
- Japan Food Chemical Research Foundation
- Urakami Foundation for Food and Food Culture Promotion
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A bacterium named 2a1-2b producing hexahydrocurcumin was isolated from human feces, showing over 99% similarity with Enterococcus avium ATCC14025(T) based on 16S ribosomal DNA sequence. The strain 2a1-2b produced optically active 5R-hexahydrocurcumin (>95% enantiomeric excess) from tetrahydrocurcumin but not curcumin, indicating the importance of the intestine in hexahydrocurcumin production.
A hexahydrocurcumin-producing bacterium named 2a1-2b was isolated from human feces. It was observed that the bacterium had more than 99% similarity with Enterococcus avium ATCC14025(T) according to 16S ribosomal DNA (rDNA) sequence. The strain 2a1-2b produced optically active 5R-hexahydrocurcumin (enantiomeric excess (e.e.)>95%) from tetrahydrocurcumin but not from curcumin. Our results showed that intestine is an important place for producing hexahydrocurcumin.
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