Journal
BIOINFORMATICS
Volume 37, Issue 17, Pages 2761-2762Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btab030
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Funding
- Swiss National Science Fundation (SNSF) [200021_192274]
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The software CapiPy is a user-friendly application designed to assist users in making informed decisions on protein immobilization methods, achieving a high success rate through protein model creation and analysis in experiments.
A Summary: Protein immobilization, while widespread to unlock enzyme potential in biocatalysis, remains tied to a trial an error approach. Nonetheless, several databases and computational methods have been developed for protein characterization and their study. CapiPy is a user-friendly application for protein model creation and subsequent analysis with a special focus on the ease of use and interpretation of the results to help the users to make an informed decision on the immobilization approach which should be ideal for a protein of interest. The package has been tested with three separate random sets of 150 protein sequences from Uniprot with more than a 70% overall success rate (see Supplementary information and Supplementary Dataset).
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