4.7 Article

ARBitR: an overlap-aware genome assembly scaffolder for linked reads

Journal

BIOINFORMATICS
Volume 37, Issue 15, Pages 2203-2205

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btaa975

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Funding

  1. European Research Council (ERC) [648143]
  2. Swedish Research Council
  3. European Research Council (ERC) [648143] Funding Source: European Research Council (ERC)

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ARBitR was developed to accurately recreate regions where draft assemblies are broken by taking overlaps into account during scaffolding.
Linked genomic sequencing reads contain information that can be used to join sequences together into scaffolds in draft genome assemblies. Existing software for this purpose performs the scaffolding by joining sequences with a gap between them, not considering potential overlaps of contigs. We developed ARBitR to create scaffolds where overlaps are taken into account and show that it can accurately recreate regions where draft assemblies are broken.

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